first E2 sensitive test results

[Chris72]

Hey guys, I'll go over a little info from my first post about my journey so far.45 yrs old, 10 years low T symptoms. Test cyp 100mg/ml IM once a wk first eight wks. had some nipple sensitivity/burning with clear discharge. Split dose to 50mg E3.5D. reduced nipple problems by about 90%, no discharge. Had my first labs done at 3 month's. barley any increase in test levels. test 336ng/dl(250-900), free 81ng/dl(50-585) up from 256 and 49. Hct 46.7%(39-48)SHBG 45(10-50)estradiol 37pg/ml(26-61)Prolactin15.2ng/ml(4.0-15.2 down from 27.1ng/dl)PSA 0.58/mL <3.90ng/mL. No pre TRT E2 or SHBG(doc says she doesn't know what SHBG has to do with testosterone).

Upped dose to 120mg a wk, 60mg E3.5D. Some of the same symptoms only worse, eraser shaped nipples/pointy nips, burning, no discharge and no lumps. Only difference this time is that I'm experiencing some occasional burning in the muscle around the left nipple. Not sure what to think because some sites say gyno affects the muscle and some say it doesn't. Could just be a muscle strain from working out .Also I'm at about 25% BF and still dropping so its hard to tell if Its just chest fat or the start of gyno, Good libido, morning and night erections are at 110%.

Two weeks into the 120mg a wk I decided to do the E2 sensitive with discounted labs because I obviously couldn't rely on the wrong estradiol test that my doctor ordered. I know I should have probably run the 120mg for at least 6 wks but the thought of boobs was killing me. Labs came back high at 46.1pg/mL(8.0-35.0) also had Hct done at hospital visit 47% up from 46.7%. Also, any way to estimate the first estradiol test?

So based on these two latest results at a minimum and the fact my test levels barley budged on the 100mg a wk for three months. Should I continue the 120mg a wk for another three wks for a total of 6 wks then test , or would it be safe to jump up to 130mg a wk or even 140mg a wk for an additional 6 wks then test? I ask this only because the labs are around $200 and my doctor wont do labs for another 6-12 months leaving me responsible for all my lab costs. Even though cost is a concern right now my main concern is always my health and safety. It took me ten years to get help but right now it feels like i'm so close but so far away from getting thing's right. Any suggestions would be helpful. I'm open to answering any relevant medical, supplement or lifestyle questions. Thanks,Chris

 

[Vince]

Are you saying that you are injecting 100 mg of testosterone cypionate weekly and your testosterone levels have not increased? But you're having nipple sensitivity?

 

[Systemlord]

Your test levels make no sense, SHBG grabs onto 97% of your testosterone and it's not as if yours is low so you should be seeing higher Total T levels. You're just a high converter meaning you convert a lot of your testosterone into estrogen. If you drink lots of alcohol you'd be better severed by stopping now.

Your case is strange and will require a knowledgeable hormone specialists and this one doesn't understand the most important aspect of male hormones (SHBG) and doesn't seem interested in balancing your hormones, you're having symptoms and it doesn't seem like your doctor even cares.

So what's your doctor plan of action regarding burning nipples?

Are you overly moody like a woman in menopause?

How do you feel besides the burning nipples?

Most of us pay out of pocket for proper care, insurance is useless for TRT.

 

[Matt Leiser]

It doesn’t hurt to order xtra labs for piece of mind imho, but changing course two weeks into a protocol change because of that result is not something I would advise. Repeat again in another 4 weeks prior to your next dosage to get your trough level and discuss an appropriate protocol change with your doctor. Unless you are symptomatic that E2 level is not that high.

Also, regarding your doctor and not knowing how SHGB affects testosterone is not a good indication you are getting the care you need. Recommend you look elsewhere for a practitioner more knowledgeable.

 

[Chris72]

My doctor doesn't have any current plans to do anything about the burning nipples, I've been experiencing this off and on for ten years now. in fact over the past ten years I've seen about five or six doctors and four endo's within the same medical systems who all told me that burning nipples wasn't something to be concerned with. As far as my mood goes I cant really tell because I have pretty bad anxiety to begin with. Nothing really obvious, I'm not crying or anything like that. Also, I rarely drink and when I do its a couple of 5oz glasses of red wine. every now and then I'll have a few more. Diets about 90% clean, no smoking, no other prescription meds or illegal drugs, workout regularly cardio five times a week.

 

[Chris72]

for the first two months I did 100mg/ml once a week, then 50mg E3.5D for next four weeks. test went from 256ng/dl to 336 and free test went from 49ng/dl to 81 over that three months.

 

[Chris72]

My goal is to try to educate my current doctor(highly unlikely), somehow find a new doctor close by or when I can afford it to switch over to Defy med.

 

[Systemlord]

Your going to educate your doctor hoping he comes around, that never works out well. The reason why your doctor will not prescribe an estrogen inhibitor is because it's not "standard of care" for insurance based doctors to prescribe estrogen inhibitors, that's the real reason behind it. Standard of care is basically instructions on how to administer TRT and manage side effects, there's no standard of care model that exists today for TRT. That's why they do nothing, because now they can't get sued for doing the wrong thing.

The lack of concern by your doctors for burning nippes is amazingly short sighted.

Defy Medical is staffed by extremely knowledgeable doctors.

 

[Vince Carter]

That's high for your TT/FT...46.1pg/mL(8.0-35.0)...remember when you say your T barely increased that that's your LOWEST point and that youre UP on the other days so there's not quite that concern there. Also notice that you're using a pretty minimal amount of test, 100mg. What you should consider with your Dr is 60mg twice per week and retest in 6 weeks.
Quite abit of nipple itch, etc is just transient and benign reaction to a new hormonal landscape and are of no concern. Of concern though is the discharge you should have that looked at closely if it returns. And as noted your Dr not willing to manage Estradiol can (will be) bothersome. Youre already converting and E follows T so if you increase your dose you can be reasonably assured E will rise as well. In your Cyp dose target your Free T to the upper 1/4 of the lab range and not so much on the TT.

 

[Chris72]

I'm three weeks into the 60mg E3.5D. I will try to have labs done in the next three to four weeks. As far as the E goes I'm pretty much maxed out on any vitamins I could take to lower E myself, might trying adding vit E just for the hell of it. I'll post my new labs as soon as I get them. Thanks for the replies.

 

[Vince]

I'm three weeks into the 60mg E3.5D. I will try to have labs done in the next three to four weeks. As far as the E goes I'm pretty much maxed out on any vitamins I could take to lower E myself, might trying adding vit E just for the hell of it. I'll post my new labs as soon as I get them. Thanks for the replies.

Does DIM really works to lower estrogen?​

https://www.excelmale.com/forum/showthread.php?8665-Does-DIM-really-works-to-lower-estrogen

 

[Vince Carter]

I'm three weeks into the 60mg E3.5D. I will try to have labs done in the next three to four weeks. As far as the E goes I'm pretty much maxed out on any vitamins I could take to lower E myself, might trying adding vit E just for the hell of it. I'll post my new labs as soon as I get them. Thanks for the replies.

If taking them for THAT reason the only thing your doing is litening your wallet. Totally worthless. Nothing lowers E that you buy OTC.

 

[Chris72]

some of the thing's I use on a daily basis, that are supposed to help eliminate or reduce estrogen, are zinc, B6, B complex, I drink lots of green tea and eat a lot of broccoli. These thing have been apart of my daily regime way before starting TRT. The only thing's I've added specifically for E would be calcium D glucarate 500mg 2X, DIM 100mg 2X, and selenium 100mg. I have know idea if there actually helping, but with the exception of the DIM, that I'm not really sure about yet, I see know problem with continuing to take them. Thanks