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A number of guys don't tolerate DHEA supplementation with anger issues or feeling PMSy or irritable. HAppened to me. The preferred route for DHEA is an oral micronized capsule which is *supposed* to survive pass thru the liver intact. Or transdermals, even sublingual. All subjective reports of feeling estrogenic but nonetheless I don't think anyone has gone to the trouble of pulling labs or any kind of study.