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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Fertility with HCG + SERM? HMG/rhFSH Impossible to get in Australia
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<blockquote data-quote="aneuman" data-source="post: 248630" data-attributes="member: 43264"><p><h4>tigermvmt,</h4><p>First thing, HCG does not "suppress LH". HCG mimics LH and because it stimulates the Leydig cells to produce more testosterone, there's an increase in estradiol, which through a negative feedback mechanism involving the pituitary and the hypothalamus, causes the anterior pituitary to reduce the production of LH. For this to work, your Leydig cells must maintain certain level of vitality. Complete testicular failure could render this treatment ineffective.</p><p></p><p>Clomid, or more specific, the enclomiphene citrate portion of clomid (62%) is selective estrogen receptor modulator that blocks that feedback mechanism I mentioned earlier and simulates lack of estrogen, which causes the hypothalamus to increase production of GnRH and the pituitary to release more LH, which increases testosterone, and FSH, which increases sperm production. For this to work, both your hypothalamus and pituitary must maintain some level of functionality, otherwise, it doesn't matter much you block the negative feedback, it won't result in increased LH/FSH.</p><p></p><p>The combination of HCG and Clomid (or just enclomiphene citrate) is effective in most cases if the HPG is still functional at some level in all three aspects (Hypothalamus, Pituitary, Gonads)</p><p></p><p>I have read that for fertility reasons, HCG doses are very high and similar to the ones you mentioned, but I have no experience with such a high dose/frequency.</p><p></p><p></p><p></p><p>Clomid and tamoxifen (2 SERMS) seems like overkill, but your doctor should probably has a reason regarding why this combination.</p><p></p><p></p><p>I do not think HCG will "stop" you from naming sperm, as a matter of fact, HCG mono therapy is usually the treatment for infertile men with doses as high as 5000 IU several times a week.</p><p></p><p></p><p>I'm not sure which "sides of SERM" you're trying to avoid. HCG also has side effects, on some people more than others, there's no such thing as a free lunch. If getting your wife pregnant is your objective, there may be some small price to pay.</p><p></p><p></p><p>I can't comment of why you can't access SERMs "there". Those are prescription medications that need to be ordered by a doctor. There're gray and black markets for everything out there but I'd stay out of it, or at least that's why I'd do.</p><p></p><p>Bottom line, depending on the reasons why you are currently infertile (testicular failure, pituitary dysfunction, etc) the combination of HCG and Clomid could work very well. In many cases, and I'm oversimplifying here, if your testicles work well but your pituitary does not, HCG alone could be a good option. If your testicles work well and your pituitary is lazy, Clomid should work well. A combination should work well in most cases. If both your pituitary and testicles are completely dysfunctional, then I have no options for you, but adoption might be a good alternative. In any case, only blood work and the evaluation of a specialist could determine your specific situation and the appropriate course of action.</p><p></p><p>Good luck</p></blockquote><p></p>
[QUOTE="aneuman, post: 248630, member: 43264"] [HEADING=3]tigermvmt,[/HEADING] First thing, HCG does not "suppress LH". HCG mimics LH and because it stimulates the Leydig cells to produce more testosterone, there's an increase in estradiol, which through a negative feedback mechanism involving the pituitary and the hypothalamus, causes the anterior pituitary to reduce the production of LH. For this to work, your Leydig cells must maintain certain level of vitality. Complete testicular failure could render this treatment ineffective. Clomid, or more specific, the enclomiphene citrate portion of clomid (62%) is selective estrogen receptor modulator that blocks that feedback mechanism I mentioned earlier and simulates lack of estrogen, which causes the hypothalamus to increase production of GnRH and the pituitary to release more LH, which increases testosterone, and FSH, which increases sperm production. For this to work, both your hypothalamus and pituitary must maintain some level of functionality, otherwise, it doesn't matter much you block the negative feedback, it won't result in increased LH/FSH. The combination of HCG and Clomid (or just enclomiphene citrate) is effective in most cases if the HPG is still functional at some level in all three aspects (Hypothalamus, Pituitary, Gonads) I have read that for fertility reasons, HCG doses are very high and similar to the ones you mentioned, but I have no experience with such a high dose/frequency. Clomid and tamoxifen (2 SERMS) seems like overkill, but your doctor should probably has a reason regarding why this combination. I do not think HCG will "stop" you from naming sperm, as a matter of fact, HCG mono therapy is usually the treatment for infertile men with doses as high as 5000 IU several times a week. I'm not sure which "sides of SERM" you're trying to avoid. HCG also has side effects, on some people more than others, there's no such thing as a free lunch. If getting your wife pregnant is your objective, there may be some small price to pay. I can't comment of why you can't access SERMs "there". Those are prescription medications that need to be ordered by a doctor. There're gray and black markets for everything out there but I'd stay out of it, or at least that's why I'd do. Bottom line, depending on the reasons why you are currently infertile (testicular failure, pituitary dysfunction, etc) the combination of HCG and Clomid could work very well. In many cases, and I'm oversimplifying here, if your testicles work well but your pituitary does not, HCG alone could be a good option. If your testicles work well and your pituitary is lazy, Clomid should work well. A combination should work well in most cases. If both your pituitary and testicles are completely dysfunctional, then I have no options for you, but adoption might be a good alternative. In any case, only blood work and the evaluation of a specialist could determine your specific situation and the appropriate course of action. Good luck [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Fertility with HCG + SERM? HMG/rhFSH Impossible to get in Australia
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