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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Fertility: Sperm count up after adding HCG to TRT
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<blockquote data-quote="HealthMan" data-source="post: 75298" data-attributes="member: 13512"><p>Dr Saya,</p><p></p><p>Maybe you can help clarify this. The attached article says that men with hypogonadotropic hypogonadism already taking HCG and adding FSH to their regimen can stop FSH once satisfactory sperm concentration is reached and spermatogenesis may be maintained with hCG alone. How is that possible? Also is there a difference between someone that started TRT using HCG and someone that only added HCG a few months later (my case) in terms of recovering fertility with the use of HCG alone while staying on TRT? In Dr Lipshultz experiment with low dose HCG to maintain fertility all the subjects started using HCG and testosterone at the same time. So looks like there is a difference between maintaining vs recovering fertility with the use of HCG. If yes what would be the mechanism responsible for that?</p><p></p><p>"In patients with acquired HGH, normal spermatogenesis can usually be restored by treatment with exogenous gonadotropins or GnRH. Human chorionic gonadotropin (hCG) therapy, which contains LH-like activity, is the most commonly used treatment in HGH for economic and compliance reasons (Conte et al 1990; Shin and Honig 2002). Human menopausal gonadotropin (hMG), which contains both FSH and LH, also has been used for replacement therapy in these patients. Normally, the treatment involves the subcutaneous administration of hCG 1500–3000 IU three times per week (March and Isidori 2002). However, congenital causes frequently require the addition of follicle-stimulating hormone (FSH). In these cases, after approximately 3 months of hCG therapy, intramuscular injections of FSH at dose of 37.5 to 75 IU are added three times per week. FSH is available in a recombinant form as well as in a highly purified urinary form. Serum testosterone levels and seminal analysis are followed during treatment. On average, it takes approximately 6 to 9 months before spermatozoa appear in the ejaculate (Haidl 2002). However, this period can be much longer (March and Isidori 2002). Once sperm concentrations reach satisfactory levels, FSH can be suspended, and spermatogenesis may be maintained with hCG alone (Siddiq and Sigman 2002)"</p><p></p><p><a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721319/#!po=12.6263" target="_blank">https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721319/#!po=12.6263</a></p></blockquote><p></p>
[QUOTE="HealthMan, post: 75298, member: 13512"] Dr Saya, Maybe you can help clarify this. The attached article says that men with hypogonadotropic hypogonadism already taking HCG and adding FSH to their regimen can stop FSH once satisfactory sperm concentration is reached and spermatogenesis may be maintained with hCG alone. How is that possible? Also is there a difference between someone that started TRT using HCG and someone that only added HCG a few months later (my case) in terms of recovering fertility with the use of HCG alone while staying on TRT? In Dr Lipshultz experiment with low dose HCG to maintain fertility all the subjects started using HCG and testosterone at the same time. So looks like there is a difference between maintaining vs recovering fertility with the use of HCG. If yes what would be the mechanism responsible for that? "In patients with acquired HGH, normal spermatogenesis can usually be restored by treatment with exogenous gonadotropins or GnRH. Human chorionic gonadotropin (hCG) therapy, which contains LH-like activity, is the most commonly used treatment in HGH for economic and compliance reasons (Conte et al 1990; Shin and Honig 2002). Human menopausal gonadotropin (hMG), which contains both FSH and LH, also has been used for replacement therapy in these patients. Normally, the treatment involves the subcutaneous administration of hCG 1500–3000 IU three times per week (March and Isidori 2002). However, congenital causes frequently require the addition of follicle-stimulating hormone (FSH). In these cases, after approximately 3 months of hCG therapy, intramuscular injections of FSH at dose of 37.5 to 75 IU are added three times per week. FSH is available in a recombinant form as well as in a highly purified urinary form. Serum testosterone levels and seminal analysis are followed during treatment. On average, it takes approximately 6 to 9 months before spermatozoa appear in the ejaculate (Haidl 2002). However, this period can be much longer (March and Isidori 2002). Once sperm concentrations reach satisfactory levels, FSH can be suspended, and spermatogenesis may be maintained with hCG alone (Siddiq and Sigman 2002)" [url]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721319/#!po=12.6263[/url] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Fertility: Sperm count up after adding HCG to TRT
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