Favorable Article on Testosterone Therapy and Pushback

Jinzang

Member
The Guardian did a very favorable article on testosterone therapy which surprised me:

“Despite my medical training, I bought into the cultural narrative that with a busy lifestyle, these symptoms are nothing more than normal ageing,” he says. A GP wrongly concluded that Vossen’s symptoms were just part and parcel of normal life. It was only after spending seven months fruitlessly doing more exercise, improving his diet and getting more sleep that Vossen sought a second opinion. “I had severely low testosterone,” he says. “I was producing about half the level I should have been.” Within three to four months of taking testosterone replacement therapy (TRT), Vossen was back to his old self.

The article was so favorable that it got pushback from the Society for Endocrinology:

This article published in the Guardian addresses the important issue of treating hypogonadism. However, we are concerned that the article will (inadvertently) serve as an advertisement for “fringe” private medical healthcare services that contradict the advice and experience of qualified NHS specialists, who have specifically trained in hormone medicine (endocrinology), with no platform offered to provide a more informed viewpoint.
 
Nice to see something positive for a change. The pushback is somewhat pathetic given the numerous NHS horror stories on display in the various forums.
 
A letter to the editor about the article. I can only conclude more doctors need to find out about Low T the hard way.

As a GP I read your article about testosterone replacement therapy with interest. I was disappointed it did not mention the 2016 review that concluded that testosterone supplementation for “low-T” is not supported by evidence. It is not due to lack of awareness that I rarely prescribe testosterone for “low-T”, but lack of evidence. I am sure that is also true of many of my colleagues.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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