Evidence of the standard E2 test's inaccuracy

[johndoesmith]

Here is a study showing the correlation of overestimation of E2 by immunoassay with C reactive protein levels





Source: http://press.endocrine.org/doi/figure/10.1210/jc.2012-3861


Further evidence of the immunoassay and it's inaccuracy



Source: http://clinchem.aaccjnls.org/content/60/3/510.long

The use of a sensitive, LC/MS assay for serum E2 measurement in males is preferred over direct immunoassays because of its greater sensitivity and lesser interference by other steroids.28 In males, estradiol is present at low concentrations in blood, but it is extraordinarily high in semen.4 Estradiol plays an important role in epididymal function and sperm maturation and is essential for normal spermatogenesis and sperm motility.4

from labcorp regarding the immunoassay https://www.labcorp.com/wps/portal/...408440&criterion=Estradiol,+Sensitive+(LC/MS)


Finally, I introduce Exhibit A: into evidence.


The purpose of "Exhibit A" is to show that while the standard test usually overestimates E2, it sometimes does the opposite, and that it's a poor way to assess where your E2 is.

 

[Nelson Vergel]

johndoesmith

Another great post, buddy! Thank you!

 

[Vince Carter]

I had the same thing, without quoting numbers and due to lab error I received both tests, same day/same blood draw...Sensitive test was higher.