madman
Super Moderator
Abstract
Introduction
Testosterone deficiency (TD) may occur after radical prostatectomy (RP). Guidance on prevalence, mechanisms, and testosterone-replacement therapy (TRT) safety remains limited.
Objective
To summarize contemporary evidence on the etiology of post-RP TD.
Methods
A PRISMA-ScR scoping review identified English-language human studies reporting the etiology of post-RP TD. Fourteen of
186 screened articles met the inclusion criteria.
Results
TD develops in 20% to 30% of men within 4 weeks and persists in 37.5% by day 90. Proposed mechanisms described in the literature include perioperative venous, ischemic, and neuroendocrine perturbations, though supporting evidence remains limited and largely indirect.
Conclusions
One-third of men experience transient or persistent TD post-RP owing to venous, ischemic, and endocrine factors; most normalize within a year. Routine androgen surveillance and prospective trials are warranted to refine the timing and long-term outcomes of administering exogenous testosterone post-RP.
3. Prevalence and postoperative recovery of testosterone
4. Mechanisms for testosterone deficiency after radical prostatectomy
5. TD after RARP and functional recovery
6. Diagnosis of testosterone deficiency
7. Management strategies for testosterone. deficiency
8. Early post-RT TRT and rational for prompt intervention
Introduction
Testosterone deficiency (TD) may occur after radical prostatectomy (RP). Guidance on prevalence, mechanisms, and testosterone-replacement therapy (TRT) safety remains limited.
Objective
To summarize contemporary evidence on the etiology of post-RP TD.
Methods
A PRISMA-ScR scoping review identified English-language human studies reporting the etiology of post-RP TD. Fourteen of
186 screened articles met the inclusion criteria.
Results
TD develops in 20% to 30% of men within 4 weeks and persists in 37.5% by day 90. Proposed mechanisms described in the literature include perioperative venous, ischemic, and neuroendocrine perturbations, though supporting evidence remains limited and largely indirect.
Conclusions
One-third of men experience transient or persistent TD post-RP owing to venous, ischemic, and endocrine factors; most normalize within a year. Routine androgen surveillance and prospective trials are warranted to refine the timing and long-term outcomes of administering exogenous testosterone post-RP.
3. Prevalence and postoperative recovery of testosterone
4. Mechanisms for testosterone deficiency after radical prostatectomy
5. TD after RARP and functional recovery
6. Diagnosis of testosterone deficiency
7. Management strategies for testosterone. deficiency
8. Early post-RT TRT and rational for prompt intervention
