Estrogen, Mistakenly Believed A Female-Only Hormone, May Explain Why Autism Rates Are Higher In Boys

Nelson Vergel

Founder, ExcelMale.com
While autism disorders appear to have a genetic basis, research suggests autism may also be linked to sex hormones. For instance, a recent European study found babies who later develop autism had been exposed to higher levels of testosterone while in the womb. This finding led scientists to question whether there might be a relationship between the disorder and estrogen, which is often mistakenly thought of as a female hormone but is also produced in males.
To understand whether estrogen might be linked to the higher rate of ASD in boys, a group of researchers from Georgia Regents University examined brain tissue samples from 13 deceased people who had ASDs and compared them to samples from 13 controls. In particular, the research team measured the expression of proteins involved in the estrogen signaling pathway: ERβ, an estrogen receptor molecule, and aromatase, an enzyme which converts testosterone to estradiol.

http://www.medicaldaily.com/estroge...may-be-key-why-autism-rates-are-higher-301918
 

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Predict estradiol, DHT, and free testosterone levels based on total testosterone

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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