madman
Super Moderator
Important case study!
Listen closely 10:40-40:35
* if you want to have a hard on you need ESTRADIOL!
KEY POINTS
* aromatase and estradiol are important for men's health
* estradiol is an ESSENTIAL METABOLITE of T
* I show you on this slide that most of the beneficial actions of testosterone are mediated via its conversion to estradiol although its only 1% all the metabolic actions are mediated by that
* Not only that but the libido and erections are mediated by testosterones conversion to estradiol so the concept of inhibiting testosterone conversion to estradiol using aromatase inhibitors is a LEGEND I mean there's NO SCIENTIFIC BASIS for that
* mitochondria are important for life, they are important not to age, they are important to maintain energy and mitochondria are improved and maintained by estradiol
Take home message
Abstract
Oestradiol (E2), a steroid hormone derived from cholesterol, has long been recognized for its central role in female reproduction and pathobiology of menopause. However, accumulating evidence underscores a critical role for E2 in the regulation of systemic metabolism in both women and men. The metabolic actions of E2 are predominantly mediated by oestrogen receptor α (encoded by ESR1), a nuclear receptor with heritable expresion patterns and tissue-specifc transcript levels highly correlated with indices of metabolic health in both sexes. Here we...
Listen closely 10:40-40:35
* if you want to have a hard on you need ESTRADIOL!
KEY POINTS
* aromatase and estradiol are important for men's health
* estradiol is an ESSENTIAL METABOLITE of T
* I show you on this slide that most of the beneficial actions of testosterone are mediated via its conversion to estradiol although its only 1% all the metabolic actions are mediated by that
* Not only that but the libido and erections are mediated by testosterones conversion to estradiol so the concept of inhibiting testosterone conversion to estradiol using aromatase inhibitors is a LEGEND I mean there's NO SCIENTIFIC BASIS for that
* mitochondria are important for life, they are important not to age, they are important to maintain energy and mitochondria are improved and maintained by estradiol
Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men (2013)
Joel S Finkelstein 1, Hang Lee 1, Sherri-Ann M Burnett-Bowie 1, J Carl Pallais 1, Elaine W Yu 1, Lawrence F Borges 1, Brent F Jones 1, Christopher V Barry 1, Kendra E Wulczyn 1, Bijoy J Thomas 1, Benjamin Z Leder 1
Take home message
Abstract
Oestradiol (E2), a steroid hormone derived from cholesterol, has long been recognized for its central role in female reproduction and pathobiology of menopause. However, accumulating evidence underscores a critical role for E2 in the regulation of systemic metabolism in both women and men. The metabolic actions of E2 are predominantly mediated by oestrogen receptor α (encoded by ESR1), a nuclear receptor with heritable expresion patterns and tissue-specifc transcript levels highly correlated with indices of metabolic health in both sexes. Here we...
