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Nelson - If my estradiol gets much above 30 then I tend to get moody and short tempered with my family. If my estradiol gets under 20 then I tend to get emotionless/clinical with how I treat those around me, and lose both emotional highs and lows. I agree that small changes don't matter a lot, but the definition of a "small change" is different from person to person. For a lot of guys, a swing from 29 to 40 might not be a lot. For me a swing from 29 to 35 is enormous.


So for me the answer is "Yes, anastrozole has a potentially very big impact on my mood; both positively and negatively". Studies or not, this is definitely the case for me and my mood is almost a barometer of what my E2 will be when I go to get blood tests.


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