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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Enclomiphene - eye floaters?
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<blockquote data-quote="Cataceous" data-source="post: 213893" data-attributes="member: 38109"><p>Unfortunately the information is lacking. The <a href="https://en.wikipedia.org/wiki/Clomifene#Other_uses" target="_blank">Wiki text</a> nicely clarifies the relationships:</p><p></p><p style="margin-left: 20px"><em>Clomifene [Clomid] consists of two stereoisomers in equal proportion: enclomifene and zuclomifene. Zuclomifene has pro-estrogenic properties, whereas enclomiphene is pro-androgenic, i.e. it promotes testosterone production through stimulation of the HPG axis. For this reason, purified enclomiphene isomer has been found to be twice as effective in boosting testosterone compared to the standard mix of both isomers.[9] Additionally, enclomifene has a halflife of just 10 hours, but zuclomifene has a halflife of 30 days—therefore if the goal is to boost testosterone, taking regular clomifene may produce far longer-lasting pro-estrogenic effects than pro-androgenic effects.</em></p><p></p><p>So even though the isomers are virtually identical they produce dramatically different effects. I have yet to see anything definitive about the reason for visual disturbances with Clomid. This suggests we don't know if the culprit is enclomiphene, zuclomiphene, or both. In any case, the association appears to be with higher doses, 50 mg and up of Clomid. I find this reassuring. I've always had some floaters, though not as bad as yours. I took 12.5 mg enclomiphene daily for 7 months without noticing any visual changes. Including my every-other-day dosing, I'm coming up on two years of use without incident. Given the lack of knowledge about Clomid and enclomiphene it's reasonable to have reservations about long-term use, as expressed in <a href="https://www.peaktestosterone.com/Clomid_Risk/" target="_blank">Curt Moyer's article</a>.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 213893, member: 38109"] Unfortunately the information is lacking. The [URL='https://en.wikipedia.org/wiki/Clomifene#Other_uses']Wiki text[/URL] nicely clarifies the relationships: [INDENT][I]Clomifene [Clomid] consists of two stereoisomers in equal proportion: enclomifene and zuclomifene. Zuclomifene has pro-estrogenic properties, whereas enclomiphene is pro-androgenic, i.e. it promotes testosterone production through stimulation of the HPG axis. For this reason, purified enclomiphene isomer has been found to be twice as effective in boosting testosterone compared to the standard mix of both isomers.[9] Additionally, enclomifene has a halflife of just 10 hours, but zuclomifene has a halflife of 30 days—therefore if the goal is to boost testosterone, taking regular clomifene may produce far longer-lasting pro-estrogenic effects than pro-androgenic effects.[/I][/INDENT] So even though the isomers are virtually identical they produce dramatically different effects. I have yet to see anything definitive about the reason for visual disturbances with Clomid. This suggests we don't know if the culprit is enclomiphene, zuclomiphene, or both. In any case, the association appears to be with higher doses, 50 mg and up of Clomid. I find this reassuring. I've always had some floaters, though not as bad as yours. I took 12.5 mg enclomiphene daily for 7 months without noticing any visual changes. Including my every-other-day dosing, I'm coming up on two years of use without incident. Given the lack of knowledge about Clomid and enclomiphene it's reasonable to have reservations about long-term use, as expressed in [URL='https://www.peaktestosterone.com/Clomid_Risk/']Curt Moyer's article[/URL]. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Enclomiphene - eye floaters?
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