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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Ejaculate changes on Clomid - High E2?
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<blockquote data-quote="abraxus" data-source="post: 122550" data-attributes="member: 24814"><p>Hey guys,</p><p></p><p>Long time lurker, first time poster. I'm a 27 year old, relatively active guy. Noticed low T symptoms, doctor decided to try fixing it (thankfully, given I didn't have the crazy low levels of some other guys seeking treatment). I recently started Clomid and switched my care to Defy Medical, got on Anastrozole and have been working to get the dosage dialed in correctly over time because my E2 levels have been all over the place despite a VERY robust response in testosterone. The only problem I'm running into that I can't find much confirmation on is that I've noticed a significant decline in ejaculate volume (think going from soaking tissues to literally a quarter of a teaspoon) and an almost jello-like consistency. This has been a problem since the first week or two on Clomid.</p><p></p><p>I haven't been able to find much on the relationship between high estradiol levels and these effects in particular, and it doesn't appear to be a known side effect of clomid (if anything, apparently some men take it to produce more, not less) or anastrozole (though the evidence of this on men is sparse to begin with). Everything I come up with talks about sperm, opposed to semen, quality or the decreased production you'd expect on test cyp without HcG. So, my question is: has anyone else encountered these side effects on Clomid? I meant to ask during my last appointment but totally forgot amid other adjustment concerns. Regimen and blood info below.</p><p></p><p>Current regimen changed as of yesterday (Previous dosage for the past several weeks):</p><p>Clomid 25mg EOD (same)</p><p>Anastrozole .125mg ED (.125mg EOD)</p><p>Vitamin D3 5000IU ED</p><p>DHEA 50mg ED</p><p>Fish oil 4g ED</p><p>Iodine 150mcg ED</p><p>Selenium 200mcg ED</p><p>Zinc 25mg ED</p><p>Magnesium 500mg ED</p><p></p><p>Initial bloods before starting Clomid:</p><p>Total Test - 453 ng/dL (264 - 916)</p><p>Free Test - 12.32 ng/dL (5 - 21)</p><p>DHT - 27 ng/dL (30 - 85) [Believed to be source of problems I had at the time]</p><p>Estradiol - 24.6 pg/mL (8 - 35)</p><p>LH - 5.4 mIU/mL (1.7 - 8.6)</p><p>FSH - 1.9 mIU/mL (1.5 - 12.4)</p><p>PSA - 0.5 ng/mL (0 - 4)</p><p>SHBG - 29.6 nmol/L (16.5 - 55.9)</p><p>IGF-1 - 188 ng/mL (98 - 282)</p><p>Zinc - 98 ug/dL (56 - 134)</p><p>Magnesium - 1.84 mg/dL (1.6 - 2.3)</p><p>DHEA-s - 210.5 ug/dL (138.5 - 475.2)</p><p>TSH - 3.15 uIU/mL (0.45 - 4.5)</p><p>Free T4 - 0.88 ng/dL (0.82 - 1.77)</p><p>Free T3 - 3.1 pg/mL (2 - 4.4)</p><p>Cholesterol - 187 mg-dL (100 - 199)</p><p>HDL - 40 mg/dL (>39)</p><p>LDL - 124 mg/dL (0 - 99)</p><p></p><p>First bloods after starting Clomid (~3 weeks):</p><p>Total Test - 788 ng/dL (264 - 916)</p><p>Free Test - 17.72 ng/dL (5 - 21)</p><p>DHT - 61 ng/dL (30 - 85) [Believed to be source of problems I had at the time]</p><p>Estradiol - 53.3 pg/mL (8 - 35)</p><p>LH - 13.3 mIU/mL (1.7 - 8.6)</p><p>FSH - 8.1 mIU/mL (1.5 - 12.4)</p><p>PSA - 0.75 ng/mL (0 - 4)</p><p>SHBG - 24.5 nmol/L (16.5 - 55.9)</p><p>IGF-1 - Didn't measure </p><p>Zinc - 106 ug/dL (56 - 134)</p><p>Magnesium - 2.3 mg/dL (1.6 - 2.3)</p><p>DHEA-s - 277 ug/dL (138.5 - 475.2)</p><p>TSH - 3.7 uIU/mL (0.45 - 4.5)</p><p>Free T4 - Not measured ng/dL (0.82 - 1.77)</p><p>Free T3 - Not measured pg/mL (2 - 4.4)</p><p>Cholesterol - Not measured mg-dL (100 - 199)</p><p>HDL - Not measured mg/dL (>39)</p><p>LDL - Not measured mg/dL (0 - 99)</p><p></p><p>Bloods after starting AI (~2 weeks) before starting Clomid (no dose change in Clomid):</p><p>Total Test - 969 ng/dL (264 - 916)</p><p>Free Test - 30.5 ng/dL (5 - 21)</p><p>DHT - 61 ng/dL (30 - 85) [Believed to be source of problems I had at the time]</p><p>Estradiol - 53.7 pg/mL (8 - 35) [Didn't move, but could be the DHEA supplement]</p><p>LH - 20.7 mIU/mL (1.7 - 8.6)</p><p>FSH - 8.1 mIU/mL (1.5 - 12.4)</p><p>PSA - 1.1 ng/mL (0 - 4)</p><p>SHBG - 24.5 nmol/L (16.5 - 55.9)</p><p>IGF-1 - 157 ng/mL (98 - 282)</p><p>Zinc - 106 ug/dL (56 - 134)</p><p>Magnesium - 2.3 mg/dL (1.6 - 2.3)</p><p>DHEA-s - 277 ug/dL (138.5 - 475.2)</p><p>TSH - 4.3 uIU/mL (0.45 - 4.5)</p><p>Free T4 - 1.16 ng/dL (0.82 - 1.77)</p><p>Free T3 - 3.0 pg/mL (2 - 4.4)</p><p>Cholesterol - 153 mg-dL (100 - 199)</p><p>HDL - 32 mg/dL (>39)</p><p>LDL - 97 mg/dL (0 - 99)</p><p></p><p>Any thoughts you guys have would be greatly appreciated. Also, anything that jumps out from the bloods that I might be able to fix with diet/exercise/supplements, I'm definitely open to. Thanks!</p></blockquote><p></p>
[QUOTE="abraxus, post: 122550, member: 24814"] Hey guys, Long time lurker, first time poster. I'm a 27 year old, relatively active guy. Noticed low T symptoms, doctor decided to try fixing it (thankfully, given I didn't have the crazy low levels of some other guys seeking treatment). I recently started Clomid and switched my care to Defy Medical, got on Anastrozole and have been working to get the dosage dialed in correctly over time because my E2 levels have been all over the place despite a VERY robust response in testosterone. The only problem I'm running into that I can't find much confirmation on is that I've noticed a significant decline in ejaculate volume (think going from soaking tissues to literally a quarter of a teaspoon) and an almost jello-like consistency. This has been a problem since the first week or two on Clomid. I haven't been able to find much on the relationship between high estradiol levels and these effects in particular, and it doesn't appear to be a known side effect of clomid (if anything, apparently some men take it to produce more, not less) or anastrozole (though the evidence of this on men is sparse to begin with). Everything I come up with talks about sperm, opposed to semen, quality or the decreased production you'd expect on test cyp without HcG. So, my question is: has anyone else encountered these side effects on Clomid? I meant to ask during my last appointment but totally forgot amid other adjustment concerns. Regimen and blood info below. Current regimen changed as of yesterday (Previous dosage for the past several weeks): Clomid 25mg EOD (same) Anastrozole .125mg ED (.125mg EOD) Vitamin D3 5000IU ED DHEA 50mg ED Fish oil 4g ED Iodine 150mcg ED Selenium 200mcg ED Zinc 25mg ED Magnesium 500mg ED Initial bloods before starting Clomid: Total Test - 453 ng/dL (264 - 916) Free Test - 12.32 ng/dL (5 - 21) DHT - 27 ng/dL (30 - 85) [Believed to be source of problems I had at the time] Estradiol - 24.6 pg/mL (8 - 35) LH - 5.4 mIU/mL (1.7 - 8.6) FSH - 1.9 mIU/mL (1.5 - 12.4) PSA - 0.5 ng/mL (0 - 4) SHBG - 29.6 nmol/L (16.5 - 55.9) IGF-1 - 188 ng/mL (98 - 282) Zinc - 98 ug/dL (56 - 134) Magnesium - 1.84 mg/dL (1.6 - 2.3) DHEA-s - 210.5 ug/dL (138.5 - 475.2) TSH - 3.15 uIU/mL (0.45 - 4.5) Free T4 - 0.88 ng/dL (0.82 - 1.77) Free T3 - 3.1 pg/mL (2 - 4.4) Cholesterol - 187 mg-dL (100 - 199) HDL - 40 mg/dL (>39) LDL - 124 mg/dL (0 - 99) First bloods after starting Clomid (~3 weeks): Total Test - 788 ng/dL (264 - 916) Free Test - 17.72 ng/dL (5 - 21) DHT - 61 ng/dL (30 - 85) [Believed to be source of problems I had at the time] Estradiol - 53.3 pg/mL (8 - 35) LH - 13.3 mIU/mL (1.7 - 8.6) FSH - 8.1 mIU/mL (1.5 - 12.4) PSA - 0.75 ng/mL (0 - 4) SHBG - 24.5 nmol/L (16.5 - 55.9) IGF-1 - Didn't measure Zinc - 106 ug/dL (56 - 134) Magnesium - 2.3 mg/dL (1.6 - 2.3) DHEA-s - 277 ug/dL (138.5 - 475.2) TSH - 3.7 uIU/mL (0.45 - 4.5) Free T4 - Not measured ng/dL (0.82 - 1.77) Free T3 - Not measured pg/mL (2 - 4.4) Cholesterol - Not measured mg-dL (100 - 199) HDL - Not measured mg/dL (>39) LDL - Not measured mg/dL (0 - 99) Bloods after starting AI (~2 weeks) before starting Clomid (no dose change in Clomid): Total Test - 969 ng/dL (264 - 916) Free Test - 30.5 ng/dL (5 - 21) DHT - 61 ng/dL (30 - 85) [Believed to be source of problems I had at the time] Estradiol - 53.7 pg/mL (8 - 35) [Didn't move, but could be the DHEA supplement] LH - 20.7 mIU/mL (1.7 - 8.6) FSH - 8.1 mIU/mL (1.5 - 12.4) PSA - 1.1 ng/mL (0 - 4) SHBG - 24.5 nmol/L (16.5 - 55.9) IGF-1 - 157 ng/mL (98 - 282) Zinc - 106 ug/dL (56 - 134) Magnesium - 2.3 mg/dL (1.6 - 2.3) DHEA-s - 277 ug/dL (138.5 - 475.2) TSH - 4.3 uIU/mL (0.45 - 4.5) Free T4 - 1.16 ng/dL (0.82 - 1.77) Free T3 - 3.0 pg/mL (2 - 4.4) Cholesterol - 153 mg-dL (100 - 199) HDL - 32 mg/dL (>39) LDL - 97 mg/dL (0 - 99) Any thoughts you guys have would be greatly appreciated. Also, anything that jumps out from the bloods that I might be able to fix with diet/exercise/supplements, I'm definitely open to. Thanks! [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Clomid for PCT, fertility or low T
Ejaculate changes on Clomid - High E2?
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