Effects of fish protein hydrolysate ingestion on endothelial function compared to whey protein hydrolysate in humans

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Fish protein-derived bioactive peptides may improve endothelial dysfunction through an antihypertensive and antioxidant effect. However, few studies have evaluated the bioactive peptides effect on vascular function. Therefore, this study investigates the effect of a single dose of fish protein hydrolysate (FPH) or whey protein hydrolysates (WPH) on endothelium-dependent dilation in nine healthy adults. The subjects ingested a single dose (20 g) of FPH, WHP or placebo (PLA). The endothelium-dependent dilation was evaluated by flow-mediated dilatation before and at 30, 60 and 120 min after supplementation. Total antioxidant capacity (TAC) of the FPH and WPH supplements was evaluated by using the Trolox equivalent antioxidant capacity assay. There was a significant increase of endothelium-dependent dilation at 30 min after WPH but not after FPH as compared to PLA. There was a significant great TAC in FPH than WPH supplement. A single dose of FPH was not able to improve endothelium-dependent dilation compared to WPH.

This study demonstrated that a single oral dose (20 g) of FPH did not improve endothelium-dependent dilation in healthy young subjects as compared to WPH. Future studies could evaluate the effect of FPH ingestion on vascular function of the others populations, such as in cardiovascular risk factors and elderly subjects, which commonly present oxidative stress.


  • JULY6-FPH-WPH-ENDOTHELIAL-FUNCTION-10.1080@09637486.2019.1635090.pdf
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