Effect of Dietary Flaxseed Intake on Circulating Sex Hormone Levels among Postmenopausal Women: A Randomized Controlled Intervention Trial

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madman

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In conclusion, our findings suggest that dietary flaxseed may modulate estrogen levels and metabolism among postmenopausal women, particularly by increasing circulating 2-hydroxyestrone levels, and consequently, improving the 2:16a-hydroxyestrone ratio. Our results add to the emerging evidence from previous intervention trials suggesting that flaxseed intake may have a role in altering sex hormone profiles which are thought to be involved in breast cancer risk (30–32). In addition, despite minor gastrointestinal side effects reported by some women, a very high adherence to the daily flaxseed intervention was achieved, suggesting it may be a feasible approach at the population level if these findings are replicated in larger trials.
 

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  • FLA-OCT31-XSEED10.1080@01635581.2018.1516789.pdf
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