ED ongoing issues

[Gman86]

Hey I know I’m not a guru on the forums but want to give my two cents as I’m a low shbg guy and i have been on trt for three years. So being low shbg we obviously suffer from high free e2 and We tend to aromatize faster as well and excret testosterone rapidly. In my case I’m i have the perfect recipe for disaster which is low shbg , highly aromatize and hyper excrete test and on top of all that I’m an anastrozole over responder. For about a year and half my sex life revolved around cialis And vigra and that was a guessing game if it would would work. I have tried every protocol under sun once ,twice, three times , daily and eod protocol with hcg and without with adex and without also with DHEA and without as well as different testosterone esthers and blends . My final solution was going to EOD injections sub q , with pregnenalone 20mg daily ,no hcg , no DHEA and micro dosing adex eod with injections

Here’s my protocol

40mg Dual blend cypionate with prop eod sub q

Adex microdose 0.05 capsule diluted with vodka intake 0.01 with shots yes that’s small of a dose has crashed me before and i have labs to prove and without it I have gyno and Ed I tried lowering the testosterone but my levels are too low so it’s my only choice

Pregenenalone 20mg everyday

Labs are 720 total t
Free t around 22
And e2 sensitive 31
Shbg 16
I have sex all the time multiple times a day I don’t always wake up with morning wood but the erection is there if I need it be. I’m 31 years old btw also a former bodybuilder so

You my friend are one persistent mothrfckr! Lol. I applaud your drive and will to keep going. And glad you found out what works for you! Hopefully your story can help others still struggling.

 

[Joe Sixpack]

I have symptoms of crashed e2 and this was when i had removed adex from the equation it’s known For altering ur e2 and testosterone ratio i have experienced this several times if I were to take it now it would give me symptoms of low e2 anxiety, insomnia and constant urination. I know it sounds crazy but it’s what’s happened luckily I don’t need it but when I have experimented it’s has occuree

Insomnia and constant urination from low E2? Very interesting. I hadn't heard of that connection to E2. I Have both of those symptoms. I'm going to have to go look at past labs to see if they correlate to my E2 levels. I Hadn't considered this.

Has anyone else seen these symptoms correspond to low E2?

 

[Cataceous]

Insomnia and constant urination from low E2? Very interesting. I hadn't heard of that connection to E2. I Have both of those symptoms. I'm going to have to go look at past labs to see if they correlate to my E2 levels. I Hadn't considered this.

Has anyone else seen these symptoms correspond to low E2?

I had undetectable estradiol for 2-3 months and did not experience those symptoms. I did lose several pounds, presumably water weight. I also lost libido and had trashed lipids.

 

[backdr10]

First time posting on here for me and I have say , as a physician , I am very impressed by the wealth of knowledge you guys provide to members. I have dealt with my own unbelievable illness as a physician and allow me to say that doctors do not get treated better than anyone else and at times much worse. As for TRTinNY’s issues , has any doctor asked why your insulin growth factor is elevated. Have you had a pituitary mri looking for empty sella syndrome or other pituitary issues? You have not had prolactin levels, c peptide, serum insulin, serum insulin binding protein 3 levels done? No growth hormone stim evaluation . If metabolic syndrome / obesity is an issue then we would expect insulin and Leptin resistance . Insulin directly affects cardiovascular health ,bp, and blood flow . Perhaps you are having issues due to contractility of the vessel wall of the penile artery along with issues secondary to hypogonadism. I am not sure if you had stated what your actual dx was, but the insulin growth factor elevation should be examined. As far as the DHEA , I seldom see satisfactory results in men. Females tend to do much better with quality third party tested pharmaceutical grade DHEA. I utilize a great deal of integrative medicine and believe that men tend to aromatize the majority of DHEA (at least the amount that actually gets absorbed and not degraded the minute it hits the digestive tract). The igf1 level needs to be investigated along with DHEA/ cortisol ratio and possiblyACTH. Polymorphism in the aromatase genes in some men will definitely cause issues as I have personally experienced and it can take a very long time to dial in the correct doses of hormone. In no way am I giving advice on what to do, but perhaps you should speak with your physician about further pituitary work up . This is just my thoughts and in no way medical advice - I leave that to your treating physician.

 

[TRTinNY]

Hi All...

So i got my blood work back and maybe this explains a lot. This bloodwork was taken on 7/29. This was taken about 3 hours after my shot.

Can anyone give input on thoughts to this?

I currently am taking .13mL (26mg) of Testosterone Cypione Daily and 300 IU HCG 2x/weekly.

Last Thursday night 8/1 i went to have sex and i couldnt get hard. I took a 100mg generic viagra and still didnt work after almost 2 hours. I took .125 anastrazole and immediately got hard (20 minutes later). Trying to make sense of all this and what to do from here. I am still having issues and need to get this under control ASAP.

 

[TRTinNY]

Anyone?

 

[Cataceous]

There's no way anastrozole is going to do much 20 minutes after taking it. It has no effect on existing estradiol. Instead it reduces the production rate, which takes more time to show up. Your testosterone seems good, even for lowish SHBG. With daily cypionate your level is probably very steady. Estradiol management seems more problematic, due in part to lack of consistency. I would revert to using a very small AI dose with extreme consistency. By small I mean 30-50 mcg EOD. The important thing is to be consistent with the dosing and then test estradiol some weeks after each change in dose. I'd only increase a little at a time as needed so that you spend enough time at various points in the normal range for free estradiol to see where you get the best results. It will take patience.

 

[TRTinNY]

There's no way anastrozole is going to do much 20 minutes after taking it. It has no effect on existing estradiol. Instead it reduces the production rate, which takes more time to show up. Your testosterone seems good, even for lowish SHBG. With daily cypionate your level is probably very steady. Estradiol management seems more problematic, due in part to lack of consistency. I would revert to using a very small AI dose with extreme consistency. By small I mean 30-50 mcg EOD. The important thing is to be consistent with the dosing and then test estradiol some weeks after each change in dose. I'd only increase a little at a time as needed so that you spend enough time at various points in the normal range for free estradiol to see where you get the best results. It will take patience.

Would I be better off lowering my testosterone dosage?

 

[Cataceous]

Would I be better off lowering my testosterone dosage?

It's something else to try. Based on SHBG of 13-17 nMol/L, your free T is calculated to be about 26 ng/dL in a reference range of 16-31. So you have some leeway.

 

[Gman86]

You need to start supplementing with DHEA. Your level is very low. DHEA also has an effect on sexual function.

I would also get a full thyroid panel done. Thyroid effects sexual functions as well.

As far as your testosterone and E2, it’s hard to say. Your numbers look about perfect, imo. I would try staying off of the ai, and seeing if the same issues occur sexually over the next week or two. And when they do, try taking the same dose of ai as you did before, and see if it helps like it did that first time. And repeat this one or two times, just to make sure that first experience wasn’t a fluke or placebo.

 

[TRTinNY]

You need to start supplementing with DHEA. Your level is very low. DHEA also has an effect on sexual function.

I would also get a full thyroid panel done. Thyroid effects sexual functions as well.

As far as your testosterone and E2, it’s hard to say. Your numbers look about perfect, imo. I would try staying off of the ai, and seeing if the same issues occur sexually over the next week or two. And when they do, try taking the same dose of ai as you did before, and see if it helps like it did that first time. And repeat this one or two times, just to make sure that first experience wasn’t a fluke or placebo.

I already know when e2 is that high I have problems. Question is whether I should maintain ai or go to a lower dose. I'm supplementing with DHEA already and it isn't really climbing much and it came from empower. Thyroid should be good. See first page of the thread.

 

[Gman86]

I already know when e2 is that high I have problems. Question is whether I should maintain ai or go to a lower dose. I'm supplementing with DHEA already and it isn't really climbing much and it came from empower. Thyroid should be good. See first page of the thread.

Sorry, just looked at your thyroid labs again. Everything looks good. Would just get RT3 checked. Make sure it’s not too high. It could be a game changer if it is, and you get it down.

What form of DHEA is it from a Empower? And what dose? I’ve heard good things about their DHEA sublingual troche.

That’s honestly a tough call in regards to what to do with your testosterone dose. All I know is, if you end up going the ai route, just know that if you feel improvements after minutes, or even a couple days, that dose is going to be too much for you once you reach steady state with it in 10-14 days. With anastrozole, you want to start feeling the improvements after 7-14 days, not minutes, hours, or even a couple days. If you notice improvements right away, once the ai continues to build up in your system over the next couple weeks, you will abolutely crash your E2. So if you do go the ai route, just keep that in mind, and start off extremely extremely low with the dose, and titrate up if needed.

 

[TRTinNY]

Guys...so heres what i found out. I had low DHEA and been treating with that. I had low Vitamin D and treating with that. i just yesterday had my dosage of anastrazole dropped to .05 which i am hoping can help keep my E2 regulated. Anyone know anything about low prolactin? my level is 3.5 and i am not taking anything known to lower it. This has been a relatively consistent number for me. Also...I am taking a daily injection of 26mg per day of testosterone cyp. I had bloodwork done 3.5 hours AFTER my injection and my testosterone level was 575 and free testosterone was 141. I feel like my total should be much higher. Any thoughts?