ED Drugs Have Benefits Beyond Treating Erectile Dysfunction

Buy Lab Tests Online

Nelson Vergel

Founder, ExcelMale.com
It’s been 18 years since the FDA approved sildenafil to treat men suffering from erectile dysfunction (ED). Under the well-known brand name Viagra, this “little blue pill” has grown to hold almost half of sexual dysfunction market share.

But, sildenafil wasn’t originally intended to help men with ED. Many have forgotten that before it was associated with a re-invigorated love life, sildenafil was a life-saving drug for people experiencing cardiovascular problems.



cGMP and PDE5 inhibitors


The groundbreaking discovery of nitric oxide (NO) in 1986 was the launch point for a novel innovation in drug discoveries. NO is a potent vasodilator that relaxes blood vessels and encourages blood flow (1).

Researchers found that NO is a critical mediator for several physiological systems that regulate blood pressure, prevent the development of atherosclerosis, and maintain penis erection. Because NO has such an incredible vasodilatory effect, it’s considered one of the most essential modulators of blood pressure.

NO accomplishes this by the formation of a substance called cyclic guanosine monophosphate (cGMP). The enzyme responsible for stopping cGMP is called phosphodiesterase enzyme 5 (PDE-5). This enzyme is always observed at high levels in patients experiencing conditions like heart failure or ventricular hypertrophy.

The discovery of PDE-5 inhibitors like sildenafil opened up a whole new approach to dealing with circulatory problems. Sildenafil provided a effective way to both restore and maintain healthy circulation, especially in people suffering from cardiovascular disease (2).

Pfizer develops a heart drug with an unusual side-effect


By the early 90s drug giant Pfizer had completed several trials of sildenafil citrate as a treatment for angina with little evidence that it was a sufficiently effective option. But, included in data collected from volunteers was anecdotal evidence that they were experiencing increased erections for several days after taking the drug.

Pfizer decided to go ahead with pilot studies with patients experiencing erectile dysfunction. In 1996 Pfizer acquired a US patent for sildenafil citrate and by March 1998 it was FDA approved to treat ED and pharmacists began dispensing it under the brand name Viagra.



Erectile dysfunction


ED is a common sexual disorder affecting millions of men worldwide. Over half the population over 40 years old experience some degree of ED. Some of the risk factors for ED are:

  • Sedentary lifestyle
  • Injuries
  • Alcohol consumption
  • Excessive stress
  • Smoking

Among the most common treatment options that are available, PDE-5 inhibitors have become the most preferred by physicians for increasing blood flow and relaxing muscles for improved erections (3).

There were worries about safety


In 2000, research was presented by Dr. Sanjay Kaul at the 49[SUP]th[/SUP] annual Scientific Session of the American College of Cardiology that suggested that there were 522 Viagra-related deaths in the first year the drug entered the market. While not explicitly blaming sildenafil the doctor was quoted by WebMd as saying, “Data appears to suggest that there’s a relatively high number of deaths and adverse cardiovascular events associated with the use of Viagra.” He also clarified that he was not implying any cause-and-effect relationship.

More recent studies have firmly established that PDE-5 inhibitors are safe, well-tolerated by most people, and have generally mild side-effects (4, 5, 6).

According to research PDE-5 inhibitors can treat more than ED


The clinical use of PDE-5 inhibitors has now come full circle. Although the original trials failed to demonstrate efficacy for the treatment of angina, hypertension, and other cardiovascular conditions, more recent studies have concluded otherwise. Due to the multiple cellular processes involving PDEs, inhibitors have found new applications in the treatment of some medical conditions (7).

Sildenafil for pulmonary hypertension


Sildenafil will help cases of pulmonary arterial hypertension (8); a lung disorder resulting from the narrowing of arteries (pulmonary arteries) that carry blood from the heart to the lungs. This narrowing causes abnormally high blood pressure in the pulmonary arteries that strains the right ventricle of the heart and causes it to expand. If it continues long enough the right ventricle will lose the ability to pump sufficient blood to the lungs, possibly leading to heart failure. Sildenafil is marketed under the brand name Revatio to treat pulmonary hypertension.

Benefits extend to diabetics


Sildenafil has been shown to reduce diabetes-induced oxidative stress and even improve insulin sensitivity to prevent type 2 diabetes (9). According to research in the Journal of Clinical Endocrinology and Metabolism, sildenafil can not only treat ED but will prevent type 2 diabetes in patients experiencing pre-diabetes, while it reduces the risk of kidney and heart disease.

It raises serum testosterone levels


20 patients at an average age of 55 years were given the PDE-5 inhibitor Tadalafil over a 12-month study period. Researchers observed sustained improvement in the men’s sexual function after one year. Tadalafil administration was associated with increased testosterone and reduced estrogen levels. The theory is that chronic exposure to tadalafil might improve the hormonal profile that regulates erectile function (10).

Can effectively treat prostate enlargement


Benign prostatic hyperplasia or BPH (prostate enlargement) and ED are not only linked by similar risk factors like age and cardiovascular disease but also at a molecular level. According to studies, PDE-5 inhibitors are a practical treatment option to relieve moderate to severe urinary symptoms of BPH (11).

PDE-5 inhibitors and premature ejaculation


Premature ejaculation (PE), while not a physically harmful condition, causes psychological distress in men who suffer it. A recent study (12) looked at whether sildenafil could increase the time to ejaculation and reduce the time needed to become erect again. The study concluded that sildenafil used alone wasn’t better than a placebo or combination treatment to treat PD.

The importance of an erectile dysfunction panel


An ED panel is a laboratory investigation looking at the possible hormonal causes of a patient’s ED. While an ED panel isn’t necessary for everyone experiencing erectile problems, it’s still a good idea.

An ED panel will determine your levels of:

  • Prolactin
  • Total and Free Testosterone levels
  • Sensitive Estradiol
  • DHT
  • TSH
  • Free T3
  • Free T4

An imbalance in any of these hormones could cause low libido/ ED. Before you consider medication to treat your ED, you should first consider investigating if there is another medical issue that may need to be addressed.

References

1) Musicki B, Champion HC, Becker RE, Liu T, Kramer MF, Burnett AL. Erection capability is potentiated by long- term sildenafil treatment: role of blood flow-induced endothelial nitric-oxide synthase phosphorylation. Mol Pharmacol.(2005)

2) Chester AH, O’Neil GS, Moncada S, Tadjkarimi S, Yacoub MH. Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries. Lancet. (1990)

3) Olsson AM, Speakman MJ, Dinsmore WW, et al. Silde- nafil citrate (Viagra) is effective and well tolerated for treating erectile dysfunction of psychogenic or mixed aetiology. International Journal of Clinical Practice. (2000)

4) Steers W, Guay AT, Leriche A, et al. Assessment of the efficacy and safety of Viagra (sildenafil citrate) in men with erectile dysfunction during long-term treatment. Int J Impot Res. (2001)

5) Porst H, Giuliano F, Glina S, et al. Evaluation of the efficacy and safety of once-a-day dosing of tadalafil 5 mg and 10 mg in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, pla- cebo controlled trial. Eur Urol. (2006)

6) Brock G, Nehra A, Lipshultz LI, et al. Safety and efficacy of vardenafil for the treatment of erectile dysfunction after radical retropubic prostatectomy. J Urol. (2003)

7) Kukreja RC. Cardiovascular protection with sildenafil following chronic inhibition of nitric oxide synthase. Br J Pharmacol. (2007)

8) Galie N, Ghofrani HA, Torbicki A, et al. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med.(2005).

9) Milani E, Nikfar S, Khorasani R, Zamani MJ, Abdollahi M.Reduction of diabetes-induced oxidative stress by phos- phodiesterase inhibitors in rats. Comp Biochem Physiol C Toxicol Pharmacol. (2005)

10) Greco EA, Pili M, Bruzziches R, Corona G, Spera A, Aversa A. Testosterone:estradiol ratio changes associated with long-term tadalafil administration: a pilot study. J Sex Med. (2006)

11) Uckert S, Oelke M, Stief CG, Andersson KE, Jonas U, Hedlund P. Immunohistochemical distribution of cAMP- and cGMP-phosphodiesterase (PDE) isoenzymes in the human prostate. Eur Urol. (2006)

12) Atan A, Basar MM, Tuncel A, Ferhat M, Agras K, Tekdo- gan U. Comparison of efficacy of sildenafil-only, silde- nafil plus topical EMLA cream, and topical EMLA-cream- only in treatment of premature ejaculation. Urology. (2006)



The post ED Drugs Have Benefits Beyond Treating Erectile Dysfunction appeared first on Testosterone Wisdom.

Continue reading...
 
Defy Medical TRT clinic doctor
Why would someone over 50 not take low dose tadalafil on a daily basis for all the many health benefits? It sounds like it would work synergistically along with TRT and other hormonal therapy...Or are there negative side effects that were not mentioned in this article?
 
Why would someone over 50 not take low dose tadalafil on a daily basis for all the many health benefits? It sounds like it would work synergistically along with TRT and other hormonal therapy...Or are there negative side effects that were not mentioned in this article?

There are negative side effects of anything you ingest. I take low dose Cialis daily and it is a great adjunct to TRT, exercise, and a good diet. For me, in addition to the obvious benefits to sex life, it has helped me be more vascular and I have got body fat down to 10%. Agree fully. Why not?
 

DragonBits

Well-Known Member
Why would someone over 50 not take low dose tadalafil on a daily basis for all the many health benefits? It sounds like it would work synergistically along with TRT and other hormonal therapy...Or are there negative side effects that were not mentioned in this article?

If it's an anti-aging supplement, why wait till you are 50 and maybe start to have problems, why not start at 20 and prevent problems from happening?
 
There are negative side effects of anything you ingest. I take low dose Cialis daily and it is a great adjunct to TRT, exercise, and a good diet. For me, in addition to the obvious benefits to sex life, it has helped me be more vascular and I have got body fat down to 10%. Agree fully. Why not?

Hey mountain man..how long have you been taking it, what dose and have you noticed any negative side effects? I just started taking 2.5 mg of tadalafil about 1 month ago and haven’t really noticed anything good or bad..I will continue at that dose for about 3 months and if nothing, I may increase the dose to 5 mg..I’m not doing it for the ED but for the Health benefits..my TRT and HGH have worked wonders for me in all other areas..I think this will be an excellent addition for anti aging benefits and healthy lifestyle addition..
 
Hey mountain man..how long have you been taking it, what dose and have you noticed any negative side effects? I just started taking 2.5 mg of tadalafil about 1 month ago and haven’t really noticed anything good or bad..I will continue at that dose for about 3 months and if nothing, I may increase the dose to 5 mg..I’m not doing it for the ED but for the Health benefits..my TRT and HGH have worked wonders for me in all other areas..I think this will be an excellent addition for anti aging benefits and healthy lifestyle addition..

5 mg. I take it every day and have for about two years. I also work out very hard every day, resistance work 45 minutes one day, and riding in air assault bike 30 minutes the others. Don’t expect much if you’re not eating well and working out.
 
No..I do work out..weights 1 hour one day and cardio one hour the next..7 days a week..eating is higher protein, carbs and lower good fats..I just want the added health benefits from it..I might increase to 5 mg..do you suffer any negative sides? I read that there can be some? I haven’t noticed any from 2.5 mg..
 
No..I do work out..weights 1 hour one day and cardio one hour the next..7 days a week..eating is higher protein, carbs and lower good fats..I just want the added health benefits from it..I might increase to 5 mg..do you suffer any negative sides? I read that there can be some? I haven’t noticed any from 2.5 mg..

No side effects.
 

DragonBits

Well-Known Member
So if I don't have ED and don't have high BP, should I use Cialis and would it be difficult to get a prescription from a doctor?

I suppose it wouldn't be difficult to pretend to have ED, that seems like the only way to get a prescription.

If it helped with insulin sensitivity that might be useful, but I am not clear how much it helps?
 

Nashtide

Member
Taking low dose cialis is one of the best decisions I’ve made in years. I did not have any issues with ED, I began taking it because I had a minor issue with bph. That episode has long passed but I continue to use the cialis daily. First, my erections went from very good to ridiculously good. Second, I get an amazing pump in the gym and my veins really pop all day. Third, it has reduced my blood pressure, especially my diastolic number.
 
Yes..I’m on 1.2 IUs 6 days on and 1 day off..I can’t say I’m doing it for the short term effects on this dose but for the long term benefits..that being said, I have noticed a good change in my bloodwork, cholesterol, lipids, sugar etc. is it the HGH, well, nothing else has changed since starting (almost 6 months now). I’ve also noticed less overall fatigue and deeper/more restful sleep. My doc said that at my dose it will take quite some time for the benefits to take effect. So I will give it at least a year and reevaluate with the doc then..but so far I am happy with the results.

I hope that helps..
 
Buy Lab Tests Online
Defy Medical TRT clinic

Sponsors

enclomiphene
nelson vergel coaching for men
Discounted Labs
TRT in UK Balance my hormones
Testosterone books nelson vergel
Register on ExcelMale.com
Trimix HCG Offer Excelmale
Thumos USA men's mentoring and coaching
Testosterone TRT HRT Doctor Near Me

Online statistics

Members online
2
Guests online
5
Total visitors
7

Latest posts

bodybuilder test discounted labs
Top