ED and Folate: An Association

CoastWatcher · Dec 1, 2017

A growing body of evidence suggests a role for homocysteine (Hcys) and folate (FA) in erectile function (EF): Hcys appears to impair EF affecting endothelium via several mechanism whereas the role of FA remains to be elucidated, besides decreasing Hcys.

To assess correlation between erectile dysfunction (ED) and serum levels of FA, Hcys, and B12, we enrolled 31 patients affected by ED (Group A; age 52.83 ± 11.89 years) and 31 healthy adults (Group B; age 49.14 ± 13.63 years).
Fasting blood samples were taken for each subject. ED was assessed by the International Index of Erectile Function-5 (IIEF-5).
IIEF-5 mean score was significantly lower in Group A than in Group B. Compared to Group B, Group A also showed significantly lower serum FA levels (5.11 ± 1.79 versus 7.9 ± 3.55 ng/ml, p < .001) and significantly higher serum Hcys levels (13.61 ± 3.55 versus 9.17 ± 2.32 µmol/L, p < .001).
This suggests that FA deficit may directly impair EF.

"Folate: a possible role in erectile dysfunction?" The Aging Male, November 2017, http://www.tandfonline.com/doi/full/10.1080/13685538.2017.1404022