Nelson Vergel
Founder, ExcelMale.com
Ecdysteroids are hormonal compounds involved in the sexual behaviour of insects as well as molting and metamorphisis. Ecdysteroids share structural similarity to testosterone and are seen as the testosterone-like compound most active in insects. They are also present in plants to deter predators.
Ecdysteroids are widely marketed to athletes as dietary supplement,
advertising to increase strength and muscle mass during resistance
training, to reduce fatigue and to ease recovery. Several studies have
reported a wide range of pharmacological effects of ecdysteroids in
mammals, most of them beneficial to the organism. In the 1980s
the most active phytoecdysteroid, ecdysterone (beta-ecdysone, a
“Russian secret”), was suspected to be used by Russian Olympic
athletes. The levels of ecdysteroids in western diet are generally low
(usually in the range of less than 1 mg·day-1), while the doses used
by bodybuilders are stated in a range of up to 1000 mg·day-1.
Extensive investigations on the possible growth-promoting effects
of ecdysterone in various animal species (rats, mice, Japanese
quail and cattle) and in humans [1-13] were reported and lots of
rumors on its misuse by athletes are circulating since then. Ecdysterone
has been demonstrated to increase protein synthesis in
skeletal muscle [14]. Gorelick et al. proposed direct or indirect
stimulation of the PI3K/Akt signaling pathway as mechanism for
this increased protein synthesis [9, 15].
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Ecdysteroids are widely marketed to athletes as dietary supplement,
advertising to increase strength and muscle mass during resistance
training, to reduce fatigue and to ease recovery. Several studies have
reported a wide range of pharmacological effects of ecdysteroids in
mammals, most of them beneficial to the organism. In the 1980s
the most active phytoecdysteroid, ecdysterone (beta-ecdysone, a
“Russian secret”), was suspected to be used by Russian Olympic
athletes. The levels of ecdysteroids in western diet are generally low
(usually in the range of less than 1 mg·day-1), while the doses used
by bodybuilders are stated in a range of up to 1000 mg·day-1.
Extensive investigations on the possible growth-promoting effects
of ecdysterone in various animal species (rats, mice, Japanese
quail and cattle) and in humans [1-13] were reported and lots of
rumors on its misuse by athletes are circulating since then. Ecdysterone
has been demonstrated to increase protein synthesis in
skeletal muscle [14]. Gorelick et al. proposed direct or indirect
stimulation of the PI3K/Akt signaling pathway as mechanism for
this increased protein synthesis [9, 15].
More information: Click here
Full Paper Attached