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It's hard to compare two different people, but I take 44mg M/W/F and have only tested my E2 on Monday morning before my dose of test. I was also taking 0.125mg of anastrazole at the same time as my injection. 5 months ago on my last labs my E2 was 40. I decided that I would stop the anastrazole starting the day of my labs and I have felt great. I wasnt having any issues, just figured I would see how I felt without it and no issues. I'm not due for labs until next month but at this point I don't really care what the number says because of how I feel. Obviously it might not work out that way for you but might be worth a try.