Reply to thread

Compounding pharmacies such as Empower offer testosterone cream. The only thing special about scrotal use is that it should be a cream rather than an alcohol-based gel. Some will find alcohol irritating in a sensitive area like that.

In theory, someone whose main problem is high estradiol could use AI monotherapy, but it's probably tricky and I haven't heard of anybody doing that long-term.

Estradiol, or E2, is the most potent estrogen (E). If you suppress estradiol then you are suppressing estrogen. Dosing with aromatase inhibitors is a very individual thing. Anastrozole is quite potent, and it's not uncommon for a total of less than 0.25 mg per week in divided doses to reduce estradiol by 20+ pg/mL. Low and slow is essential.