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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
E2 fluctuation makes no sense
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<blockquote data-quote="Cataceous" data-source="post: 241428" data-attributes="member: 38109"><p>Getting back to your original question: 200 mg per week is a whopping dose, camouflaged by using trough serum measurements. With these trough TT values running 1,000-1,200 ng/dL, you can expect the peak values to be two to three times higher. For example, your peak TT may run about 2,500 ng/dL, implying that your average value is about 1,800 ng/dL. Going to E3D injections had the desired effect, stabilizing serum testosterone by moving peaks and troughs closer to the average value. What you weren't expecting was the stark evidence of excessive dosing; trough testosterone moved from ~1,000 ng/dL closer to the average of ~1,800. The results might be easier to understand if you consider that the average healthy young guy naturally produces 6-7 mg of testosterone per day, while you're taking an average of 20 mg per day—about three times as much.</p><p></p><p>The subsequent high estradiol measurement is harder to explain, although it's nothing unreasonable compared to the testosterone levels you have earlier in the injection cycles. In other words, estradiol typically runs about 0.3-0.6% of testosterone, so your original measurements in the 20s pg/mL were on the low side even relative to trough TT of ~1,000 ng/dL. The current figure of 74 pg/mL is slightly high relative to trough TT, but is only 0.3% of your possible peak TT.</p><p></p><p>In your shoes I would not use an AI. Instead I would cut the testosterone cypionate dose to 50 mg twice a week and ride out the withdrawal for a few months before assessing things.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 241428, member: 38109"] Getting back to your original question: 200 mg per week is a whopping dose, camouflaged by using trough serum measurements. With these trough TT values running 1,000-1,200 ng/dL, you can expect the peak values to be two to three times higher. For example, your peak TT may run about 2,500 ng/dL, implying that your average value is about 1,800 ng/dL. Going to E3D injections had the desired effect, stabilizing serum testosterone by moving peaks and troughs closer to the average value. What you weren't expecting was the stark evidence of excessive dosing; trough testosterone moved from ~1,000 ng/dL closer to the average of ~1,800. The results might be easier to understand if you consider that the average healthy young guy naturally produces 6-7 mg of testosterone per day, while you're taking an average of 20 mg per day—about three times as much. The subsequent high estradiol measurement is harder to explain, although it's nothing unreasonable compared to the testosterone levels you have earlier in the injection cycles. In other words, estradiol typically runs about 0.3-0.6% of testosterone, so your original measurements in the 20s pg/mL were on the low side even relative to trough TT of ~1,000 ng/dL. The current figure of 74 pg/mL is slightly high relative to trough TT, but is only 0.3% of your possible peak TT. In your shoes I would not use an AI. Instead I would cut the testosterone cypionate dose to 50 mg twice a week and ride out the withdrawal for a few months before assessing things. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
E2 fluctuation makes no sense
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