Thank you for the details of what you were experiencing from PT-141 and your response to ECT. I have treatment resistant bipolar/mixed state, non-restorative sleep & CPTSD. Anhedonia is ever present in my life. My psychiatrist suggested ECT but as I'm caring for my wife, who is into her 17th month of rapidly progressing Alzheimer's, I need to be present and functional, so I just limp along, emotionally, day after day.
She's not the first doctor to discuss ECT. When we lived in Maryland, a noted psychiatrist at the NIH, whom I was going to, gave me a referral to a doctor who did ECT, exclusively, but I was(and still am)fearful of significant memory loss. But, again, ECT is moot at this time.
Also on TRT and for a day or two after my injection, my mood is a bit better. Currently doing 70 mg 2X weekly but wondering if 50 mg 3X weekly might be better. However, without consistently restorative sleep, with or without mood problems, you can't feel mentally or physically good.