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General Health & Fitness
Health & Wellness
Dr. David Diamond: Exposing the cholesterol myth
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<blockquote data-quote="xqfq" data-source="post: 154101" data-attributes="member: 38167"><p>I'd highly encourage you to read more about these new drugs with an open mind.</p><p></p><p>PCSK9 inhibitors work using an entirely different mechanism than statins, and do not have the associated side effects.</p><p></p><p>Statins slow the body's own production of cholesterol at the cell level, and do so in every cell in the body. This has the effect of lowering LDL particle count, but it also means that if the statin is inappropriately dosed (or the individual is just susceptible to the side effects), some cells may not get enough cholesterol (that's my layman's understanding). There are also side effects of the inhibition of the enzyme directly, e.g. needing to supplement with Coq10, etc.</p><p></p><p>PCSK9 inhibitors do something totally different: they up-regulate the number of LDL receptors inside your cells. So the LDL particles can still fly around inside the body, and when a cell wants some cholesterol, it can get it. But it means there's less free-floating LDL that's /not/ being used by a cell at a given time, so it reduces the LDL particle count. It's like adding a bunch of lanes to a freeway, and statins are like slowing the freeway (sort of).</p><p></p><p>Total cholesterol decreases but that has no effect on a cell's ability to get cholesterol when needed. Total cholesterol is just a measure of how much cholesterol (sum) is in the blood, not a measure of how well cells can get or create cholesterol.</p></blockquote><p></p>
[QUOTE="xqfq, post: 154101, member: 38167"] I'd highly encourage you to read more about these new drugs with an open mind. PCSK9 inhibitors work using an entirely different mechanism than statins, and do not have the associated side effects. Statins slow the body's own production of cholesterol at the cell level, and do so in every cell in the body. This has the effect of lowering LDL particle count, but it also means that if the statin is inappropriately dosed (or the individual is just susceptible to the side effects), some cells may not get enough cholesterol (that's my layman's understanding). There are also side effects of the inhibition of the enzyme directly, e.g. needing to supplement with Coq10, etc. PCSK9 inhibitors do something totally different: they up-regulate the number of LDL receptors inside your cells. So the LDL particles can still fly around inside the body, and when a cell wants some cholesterol, it can get it. But it means there's less free-floating LDL that's /not/ being used by a cell at a given time, so it reduces the LDL particle count. It's like adding a bunch of lanes to a freeway, and statins are like slowing the freeway (sort of). Total cholesterol decreases but that has no effect on a cell's ability to get cholesterol when needed. Total cholesterol is just a measure of how much cholesterol (sum) is in the blood, not a measure of how well cells can get or create cholesterol. [/QUOTE]
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General Health & Fitness
Health & Wellness
Dr. David Diamond: Exposing the cholesterol myth
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