Dosage question

Jacklg250

New Member
Ok folks, doc prescribed 1mg anastrozole. i currently take 100mg once per week of testosterone cyp.

latest labs from last week stated that my estradiol levels were at 52.9 pg/ml and T-levels were at 950 ng/dL.

Free testosterone: 190 pg/ml
Free testosterone %: 2.0
SHBG: 30.4 nmol/L

(If you'd like any more lab info let me know)

In your opinion, how would you dose this AI?
 
I would start with cutting the pills into quarters. Take 0.25 mg twice a week to start as it is very powerful drug.
 
If your E is at 52 on just 100mg T a week you might need that amount of AI.
As others suggested, start low, maybe 0.5 a week, and give it a few weeks before eventually increasing the dosage.
 
I agree with the folks saying to start slow with anastrozole especially if you dont have any symptoms of high estradiol. The last thing you wanna do is crash your estradiol. 0.25mg every 3.5 days and then test. I started with 0.25mg 2x a week but had to increase to 3x a week.
 
Assuming that your E2 was the sensitive assay I would take .50 ai initially then take .25 ai every 5 days and retest in 6 weeks or so to determine if dose is appropriate. As stated this ai is very strong and works pretty fast as well and 52.9 is not that high. I was in the same boat E2 was 52 on sensitive then went down to 18 on .25 every 4 days. Good luck.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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