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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Does anyone use Nandrolone (Deca Durabolin) ?
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<blockquote data-quote="Nelson Vergel" data-source="post: 39522" data-attributes="member: 3"><p><strong>THERAPEUTIC USES</strong></p><p></p><p>A number of clinical studies using a variety of experimental designs have shown that the potent anabolic effects of AAS have positive benefits to various patient populations.<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-58" target="_blank">[SUP]58[/SUP]</a> </p><p></p><p>Physiologic replacement doses of testosterone have been used therapeutically to restore hormone levels in hypogonadal men, thereby increasing fat-free mass, muscle size and strength, and bone density<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-8" target="_blank">[SUP]8,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-16" target="_blank">[SUP]16,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-48" target="_blank">[SUP]48,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-87" target="_blank">[SUP]87,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-99" target="_blank">[SUP]99[/SUP]</a>;</p><p>improve mood and alleviate depression<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-70" target="_blank">[SUP]70,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-82" target="_blank">[SUP]82,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-102" target="_blank">[SUP]102[/SUP]</a>;</p><p>increase body weight, muscle mass, and strength in eugonadal patients with secondary wasting syndromes, such as infection with HIV,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-10" target="_blank">[SUP]10,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-36" target="_blank">[SUP]36,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-74" target="_blank">[SUP]74,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-77" target="_blank">[SUP]77,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-78" target="_blank">[SUP]78,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-89" target="_blank">[SUP]89[/SUP]</a> when maintaining lean body mass may be beneficial for long-term survival<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-25" target="_blank">[SUP]25[/SUP]</a>; and</p><p>augment muscle mass in older men and prevent age-related sarcopenia that contributes to frailty and falls.<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-15" target="_blank">[SUP]15,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-17" target="_blank">[SUP]17,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-79" target="_blank">[SUP]79,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-88" target="_blank">[SUP]88,[/SUP]</a>,<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-98" target="_blank">[SUP]98[/SUP]</a></p><p></p><p></p><p><strong>Future Applications</strong></p><p></p><p>A more widely accepted use of androgen therapy has been hampered by the lack of orally active preparations with good efficacy and safe profile. Progress has been limited in developing synthetic molecules that could separate the desired anabolic effects from other androgenic effects that were undesirable or had dose-limiting effects. A new class of molecules is currently under investigation. The so-called selective androgen receptor modulators exhibit tissue specificity in targeting the AR.<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-64" target="_blank">[SUP]64[/SUP]</a> In the future, it is likely that testosterone derivatives will be further tested for a broad range of medical conditions.In orthopaedic sports medicine, we might anticipate the novel use of AAS as adjuvant medical therapy in fracture healing, soft tissue healing, or postoperative rehabilitation. Recent studies demonstrate that AASs promote the healing of muscle contusion injury<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-6" target="_blank">[SUP]6[/SUP]</a> and that AASs can reduce immobilization-induced muscle atrophy.<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-95" target="_blank">[SUP]95[/SUP]</a> Low-dose AASs have also been shown to improve functional outcome in elderly women after hip fracture, exhibiting a beneficial effect on muscle mass and bone mineral density.<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-39" target="_blank">[SUP]39[/SUP]</a></p><p></p><p></p><p><strong>Current Concepts in Anabolic-Androgenic Steroids</strong></p><p></p><p><a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/search?author1=Nick+A.+Evans&sortspec=date&submit=Submit" target="_blank">Nick A. Evans</a>, MD<a href="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#corresp-1" target="_blank">*</a></p><p></p><p>Am J Sports Med<strong> March 2004 </strong>vol. 32 no. 2 <strong>534-542</strong></p></blockquote><p></p>
[QUOTE="Nelson Vergel, post: 39522, member: 3"] [B]THERAPEUTIC USES[/B] A number of clinical studies using a variety of experimental designs have shown that the potent anabolic effects of AAS have positive benefits to various patient populations.[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-58"][SUP]58[/SUP][/URL] Physiologic replacement doses of testosterone have been used therapeutically to restore hormone levels in hypogonadal men, thereby increasing fat-free mass, muscle size and strength, and bone density[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-8"][SUP]8,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-16"][SUP]16,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-48"][SUP]48,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-87"][SUP]87,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-99"][SUP]99[/SUP][/URL]; improve mood and alleviate depression[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-70"][SUP]70,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-82"][SUP]82,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-102"][SUP]102[/SUP][/URL]; increase body weight, muscle mass, and strength in eugonadal patients with secondary wasting syndromes, such as infection with HIV,[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-10"][SUP]10,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-36"][SUP]36,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-74"][SUP]74,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-77"][SUP]77,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-78"][SUP]78,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-89"][SUP]89[/SUP][/URL] when maintaining lean body mass may be beneficial for long-term survival[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-25"][SUP]25[/SUP][/URL]; and augment muscle mass in older men and prevent age-related sarcopenia that contributes to frailty and falls.[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-15"][SUP]15,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-17"][SUP]17,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-79"][SUP]79,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-88"][SUP]88,[/SUP][/URL],[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-98"][SUP]98[/SUP][/URL] [B]Future Applications[/B] A more widely accepted use of androgen therapy has been hampered by the lack of orally active preparations with good efficacy and safe profile. Progress has been limited in developing synthetic molecules that could separate the desired anabolic effects from other androgenic effects that were undesirable or had dose-limiting effects. A new class of molecules is currently under investigation. The so-called selective androgen receptor modulators exhibit tissue specificity in targeting the AR.[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-64"][SUP]64[/SUP][/URL] In the future, it is likely that testosterone derivatives will be further tested for a broad range of medical conditions.In orthopaedic sports medicine, we might anticipate the novel use of AAS as adjuvant medical therapy in fracture healing, soft tissue healing, or postoperative rehabilitation. Recent studies demonstrate that AASs promote the healing of muscle contusion injury[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-6"][SUP]6[/SUP][/URL] and that AASs can reduce immobilization-induced muscle atrophy.[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-95"][SUP]95[/SUP][/URL] Low-dose AASs have also been shown to improve functional outcome in elderly women after hip fracture, exhibiting a beneficial effect on muscle mass and bone mineral density.[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#ref-39"][SUP]39[/SUP][/URL] [B]Current Concepts in Anabolic-Androgenic Steroids[/B] [URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/search?author1=Nick+A.+Evans&sortspec=date&submit=Submit"]Nick A. Evans[/URL], MD[URL="http://ajs.sagepub.com.ezproxyhost.library.tmc.edu/content/32/2/534.full#corresp-1"]*[/URL] Am J Sports Med[B] March 2004 [/B]vol. 32 no. 2 [B]534-542[/B] [/QUOTE]
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Clinical Use of Anabolics and Hormones
Clinical Use of Anabolics and Hormones
Does anyone use Nandrolone (Deca Durabolin) ?
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