Reply to thread

Message: <blockquote data-quote="Gene Devine" data-source="post: 8969" data-attributes="member: 4">Two things to always keep in mind about HCG at large dosages:1.  It can/will cause leydig cell receptor saturation leading to receptor desensitization resulting in the HCG not doing what it is supposed to do.2.  It can/will cause an increase in intratesticular estrogen levels that an AI has little effect in controlling. For these reasons, and others, it's best to start out at lower dosages and see how your testes fair and how you feel and slowly titrate up from there.</blockquote>