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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Do you cycle HCG?
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<blockquote data-quote="madman" data-source="post: 204731" data-attributes="member: 13851"><p>Unfortunately even when using hCG along with exogenous testosterone the HPTA is still shut down.</p><p></p><p>hCG is a direct luteinizing hormone (LH) analog and mimics LH which stimulates the Leydig cells to produce and release ITT (intratesticular testosterone).</p><p></p><p>Although.....<strong><em>* It is currently unknown if long-term administration of HCG can lead to side effects such as gonadotropin resistance.</em></strong></p><p><strong><em></em></strong></p><p><strong><em></em></strong></p><p><strong><em>*HCG’s ability to preserve spermatogenesis, and even improve semen parameters in patients who had been using exogenous testosterone, have been established (10-13). <u>Vicari et al. looked at long term hCG treatment in 17 men with isolated hypogonadotropic hypogonadism, observing a significant increase in testicular volume, in a time-dependent manner, and testosterone, at 15 and 24 months of treatment</u> (13)</em></strong></p><p></p><p></p><p></p><p></p><p>Maybe there is a benefit to taking short-term breaks throughout the year depending on your goals but even then I would keep it to a minimum.</p><p></p><p>For all, we know there may very well be long-term consequences from a testosterone-only protocol due to long-term suppression of ITT.</p><p></p><p><strong><em>*A replacement regimen with combined hCG/rFSH mimics physiologic steroid hormone profiles better than a substitution with exogenous testosterone. </em><u><em>The documented differences in steroid profiles on testosterone replacement in hypogonadal males with absent or severely reduced endogenous LH and FSH secretion may have long-term consequences for health and wellbeing</em></u><em>.</em></strong> <strong><em><u>Specifically, body composition, bone health, glucose, and lipid metabolism, salt and water balance, cognition, mood, sleep, and sexual function could be affected</u>. </em></strong>The steroidogenic differences could also be relevant for gonadotropin-suppressive treatments with long-acting testosterone preparations in males with primary hypogonadism. To what extent this hypothesis is true, should be addressed in future clinical studies.</p></blockquote><p></p>
[QUOTE="madman, post: 204731, member: 13851"] Unfortunately even when using hCG along with exogenous testosterone the HPTA is still shut down. hCG is a direct luteinizing hormone (LH) analog and mimics LH which stimulates the Leydig cells to produce and release ITT (intratesticular testosterone). Although.....[B][I]* It is currently unknown if long-term administration of HCG can lead to side effects such as gonadotropin resistance. *HCG’s ability to preserve spermatogenesis, and even improve semen parameters in patients who had been using exogenous testosterone, have been established (10-13). [U]Vicari et al. looked at long term hCG treatment in 17 men with isolated hypogonadotropic hypogonadism, observing a significant increase in testicular volume, in a time-dependent manner, and testosterone, at 15 and 24 months of treatment[/U] (13)[/I][/B] Maybe there is a benefit to taking short-term breaks throughout the year depending on your goals but even then I would keep it to a minimum. For all, we know there may very well be long-term consequences from a testosterone-only protocol due to long-term suppression of ITT. [B][I]*A replacement regimen with combined hCG/rFSH mimics physiologic steroid hormone profiles better than a substitution with exogenous testosterone. [/I][U][I]The documented differences in steroid profiles on testosterone replacement in hypogonadal males with absent or severely reduced endogenous LH and FSH secretion may have long-term consequences for health and wellbeing[/I][/U][I].[/I][/B] [B][I][U]Specifically, body composition, bone health, glucose, and lipid metabolism, salt and water balance, cognition, mood, sleep, and sexual function could be affected[/U]. [/I][/B]The steroidogenic differences could also be relevant for gonadotropin-suppressive treatments with long-acting testosterone preparations in males with primary hypogonadism. To what extent this hypothesis is true, should be addressed in future clinical studies. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
When Testosterone Is Not Enough
Do you cycle HCG?
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