Do men with normal testosterone–oestradiol ratios benefit from letrozole for the treatment of male infertility?

[madman]

In conclusion, the role of aromatase inhibitors such as letrozole in the management of male infertility has been limited to men with testosterone– oestradiol ratio of less than 10 since the publication of the study by Pavlovich et al. (2001). Our data suggest that treatment with letrozole improves testosterone–oestradiol ratio even in men with normal testosterone–oestradiol ratio, and its role can potentially be extended to all men with severe idiopathic oligospermia regardless of their initial testosterone–oestradiol ratio, as it is a relatively well-tolerated drug with no serious adverse effects. Considering the relatively small sample size of this study, additional studies are still needed to validate these findings and show that improved sperm parameters and testosterone–oestradiol ratios achieved with letrozole can translate into improved pregnancy outcomes.

 

[lowe2sucks]

We all know taking AI to treat hypogonadism is beyond stupid since treating hypogonadism is not only increasing testosterone you want your e2 higher as well if you had low estradiol since it's part of hypogonal symptoms thus AI therapy's is shit