Do I Have Primary Hypogonadism ?

G1122

New Member
Was on 25mg Clomid EOD. After 4 weeks I did labs and had these results:
LH: 7.5 (1.7-8.6)
TT: 330 (264-916)

Does this mean I'm primary or is 4 weeks not enough time for the testes to recover?

I was using HCG while on TRT, but obviously not frequently enough. I was simply doing 250iu 1-2x/week and got lax with my use where previously I'd used more. Should I give it more time or abandon my hope of PCT?

I'd never gotten an initial diagnosis and was put on T before testing LH/FSH so it's possible I was primary all along. I'm 28 y/o and don't see physical issues with my testes and things seemed fine in my early 20's before I gained weight and got very fatigued.
 
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Your LH doesn't look bad, 7.5 after 4 weeks. I would think your total T would be higher. I would continue the protocol. Hopefully your results will improve. What was your T level before you started trt?
 
TT was at 250 like 4 years ago. Unfortunately didn't get initial LH/FSH readings. I had terrible side effects so I got off clomid, but I wonder if I push through for another month or so that my testes will "wake up". Things have obviously flatlined after stopping the Clomid. This is very concerning as I'd always thought I was secondary and cannot for the life of me reason why at 28 I'd be primary other than inconsistent HCG usage so I feel now a little lost.
 
If your secondary, HCG should raise your testosterone. You could just try HCG and see what results you get.

Do you suggest that over really low-dose clomid (12.5mg EOD)? The serious side effects became really pronounced when my Dr in response to the above labs doubled my dose to 25mg OD (instead of EOD). I wonder if taking a step back and giving more time would be more prudent as opposed to HCG due to FSH activity?
 
Do you suggest that over really low-dose clomid (12.5mg EOD)? The serious side effects became really pronounced when my Dr in response to the above labs doubled my dose to 25mg OD (instead of EOD). I wonder if taking a step back and giving more time would be more prudent as opposed to HCG due to FSH activity?
I've never used clomid but it does seem that patients do better on a lower dose. I believe but don't know for sure that doctor Saya use 12.5 mg of clomid for his patients.
 
Your total test production compared to LH looks a little sluggish, but not in the tank. I've seen this with other guys in the past where they had similar results, and they had one testicle doing most of the work, and one (1) that was under-performing.

Might want to run it by a Urologist or someone who can provide a gonadal testicular exam.. It appears Clomid is stimulating adequate LH production with the HPTA, so having a 7.5 LH result is in the upper limit to produce endogenous test. HCG would just mimic LH, essentially doing the same thing, which again at this point is a bit sluggish.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

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Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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