madman
Super Moderator
CONCLUSION
In summary, 5a-RI therapy is not associated with consistent and significant increases in serum T levels. Men with low serum T concentrations may have a greater likelihood of experiencing a rise in serum T with 5a-RI treatment. Based on the very modest increase in serum T in those studies where such a rise was observed, it is unlikely that this change is clinically meaningful. We advance the hypothesis that the rise in serum T in response to 5a-RI therapy, when it occurs, results from re-equilibration of SHBG binding to T, as serum concentrations of 5a-DHT decline.
In summary, 5a-RI therapy is not associated with consistent and significant increases in serum T levels. Men with low serum T concentrations may have a greater likelihood of experiencing a rise in serum T with 5a-RI treatment. Based on the very modest increase in serum T in those studies where such a rise was observed, it is unlikely that this change is clinically meaningful. We advance the hypothesis that the rise in serum T in response to 5a-RI therapy, when it occurs, results from re-equilibration of SHBG binding to T, as serum concentrations of 5a-DHT decline.
