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General Health & Fitness
Nutrition and Supplements
DIM - Anti-androgen Clarification
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<blockquote data-quote="Cataceous" data-source="post: 177247" data-attributes="member: 38109"><p>The claim for DIM has not been about estradiol reduction, but about steering metabolism in a safer direction. The effectiveness of CDG at typical doses is suspect:</p><p></p><p style="margin-left: 20px"><em>However, a problem occurs when humans take this as an oral supplement. Although it appears to be safe even at high doses, very high doses are required for its effects (100mg/kg minimum, near maximal effects at 200mg/kg) and this would even only theoretically assure some protection against toxins that are glucuronidated. If a toxin is subject to another detoxification pathway (such as conjugation by glutathione) then Glucaric acid will serve no benefit.</em></p> <p style="margin-left: 20px"><em>...</em></p> <p style="margin-left: 20px"><em>Furthermore, all steroid hormones in the body (testosterone, estrogen, <a href="https://examine.com/topics/dhea/" target="_blank">DHEA</a>, etc.) are also glucuronidated. If using an oral dose that reduces the toxin, these hormones will also all be reduced for a short time.</em></p> <p style="margin-left: 20px"><em>...</em></p> <p style="margin-left: 20px"><em>Using calcium-D-glucarate as a daily preventative supplement does not appear to be a prudent idea, due to its lack of reliability even in theory and high doses used. However, a single acute dose of this supplement prior to <em>known</em> exposure to toxins that are glucuronidated (such as both benzopyrene and polyaromatic hydrocarbon compounds produced in the cooking of meat products) might be more prudent and potentially useful.</em></p><p>[<a href="https://examine.com/supplements/calcium-d-glucarate/" target="_blank">1</a>]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 177247, member: 38109"] The claim for DIM has not been about estradiol reduction, but about steering metabolism in a safer direction. The effectiveness of CDG at typical doses is suspect: [INDENT][I]However, a problem occurs when humans take this as an oral supplement. Although it appears to be safe even at high doses, very high doses are required for its effects (100mg/kg minimum, near maximal effects at 200mg/kg) and this would even only theoretically assure some protection against toxins that are glucuronidated. If a toxin is subject to another detoxification pathway (such as conjugation by glutathione) then Glucaric acid will serve no benefit.[/I][/INDENT] [INDENT][I]...[/I][/INDENT] [INDENT][I]Furthermore, all steroid hormones in the body (testosterone, estrogen, [URL='https://examine.com/topics/dhea/']DHEA[/URL], etc.) are also glucuronidated. If using an oral dose that reduces the toxin, these hormones will also all be reduced for a short time.[/I][/INDENT] [INDENT][I]...[/I][/INDENT] [INDENT][I]Using calcium-D-glucarate as a daily preventative supplement does not appear to be a prudent idea, due to its lack of reliability even in theory and high doses used. However, a single acute dose of this supplement prior to [I]known[/I] exposure to toxins that are glucuronidated (such as both benzopyrene and polyaromatic hydrocarbon compounds produced in the cooking of meat products) might be more prudent and potentially useful.[/I][/INDENT] [[URL='https://examine.com/supplements/calcium-d-glucarate/']1[/URL]] [/QUOTE]
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DIM - Anti-androgen Clarification
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