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General Health & Fitness
Nutrition and Supplements
DIM - Anti-androgen Clarification
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<blockquote data-quote="DS3" data-source="post: 177229" data-attributes="member: 18514"><p>Do you have anything tangible to go from to form a position either way or just speculation? Is there data?</p><p></p><p>I don't see anything in the available research that suggests decreased T levels, Free T, decreased muscular hypertrophy as a result, or anything resembling this. The research suggests focused anti-androgenic activity within the prostate.</p><p></p><p>So, as an example, we know that 3a-hydroxysteroid-dehydrogenase readily inactivates DHT within muscle tissue, significantly limiting DHT's effect in skeletal muscle.</p><p></p><p>What we don't know is whether or not DIM is inactivated in a similar fashion (not via the same enzyme) within muscle tissue, rendering its anti-androgenic properties ineffective. So, could DIM produce anti-androgenic effects in the prostate and other DHT-specific sites (hair, skin) yet produce little to no effect in muscle tissue? Or does DIM bind significantly to the AR in muscle tissue as it does in the prostate and negatively impact TRT outcomes?</p></blockquote><p></p>
[QUOTE="DS3, post: 177229, member: 18514"] Do you have anything tangible to go from to form a position either way or just speculation? Is there data? I don't see anything in the available research that suggests decreased T levels, Free T, decreased muscular hypertrophy as a result, or anything resembling this. The research suggests focused anti-androgenic activity within the prostate. So, as an example, we know that 3a-hydroxysteroid-dehydrogenase readily inactivates DHT within muscle tissue, significantly limiting DHT's effect in skeletal muscle. What we don't know is whether or not DIM is inactivated in a similar fashion (not via the same enzyme) within muscle tissue, rendering its anti-androgenic properties ineffective. So, could DIM produce anti-androgenic effects in the prostate and other DHT-specific sites (hair, skin) yet produce little to no effect in muscle tissue? Or does DIM bind significantly to the AR in muscle tissue as it does in the prostate and negatively impact TRT outcomes? [/QUOTE]
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DIM - Anti-androgen Clarification
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