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General Health & Fitness
Nutrition and Supplements
DIM - Anti-androgen Clarification
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<blockquote data-quote="DS3" data-source="post: 177222" data-attributes="member: 18514"><p>So the results of the study determine that DIM competes with DHT for AR activity in LNCaP cells and in Recombinant AR Protein. The reported downstream effect on that being reduced risk of prostate cancer in men. The study does not indicate that all ARs are affected by DIM, nor does it suggest that skeletal muscle is negatively affected due to competitive binding at the AR in skeletal muscle. </p><p></p><p>When I have reviewed the small amount of research available, DIM's competitive activity has been discussed in regard to reduced risk of prostate cancer and estrogen-dependent cancers. I haven't found anything suggesting that all ARs throughout the body are affected by DIM. </p><p></p><p><strong>I'n addition to effects on proliferation and apoptosis, DIM acts as an antiandrogen in prostate cancer cell lines. This study characterized the effects of prostatic DIM on the androgen receptor (AR) in patients with prostate cancer."</strong></p><p><strong></strong></p><p><strong>[URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759426/[/URL]</strong></p><p></p><p>I am questioning whether DIM has specific anti-androgenic activity (specific ARs as previously mentioned) versus broad-spectrum competitive-binding at the AR. </p><p></p><p>What are your thoughts?</p></blockquote><p></p>
[QUOTE="DS3, post: 177222, member: 18514"] So the results of the study determine that DIM competes with DHT for AR activity in LNCaP cells and in Recombinant AR Protein. The reported downstream effect on that being reduced risk of prostate cancer in men. The study does not indicate that all ARs are affected by DIM, nor does it suggest that skeletal muscle is negatively affected due to competitive binding at the AR in skeletal muscle. When I have reviewed the small amount of research available, DIM's competitive activity has been discussed in regard to reduced risk of prostate cancer and estrogen-dependent cancers. I haven't found anything suggesting that all ARs throughout the body are affected by DIM. [B]I'n addition to effects on proliferation and apoptosis, DIM acts as an antiandrogen in prostate cancer cell lines. This study characterized the effects of prostatic DIM on the androgen receptor (AR) in patients with prostate cancer." [URL unfurl="true"]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4759426/[/URL][/B] I am questioning whether DIM has specific anti-androgenic activity (specific ARs as previously mentioned) versus broad-spectrum competitive-binding at the AR. What are your thoughts? [/QUOTE]
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General Health & Fitness
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DIM - Anti-androgen Clarification
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