What's interesting about DIM's potential anti-androgen capabilities is that there is very little research on the topic.
However, this study is very interesting. "DIM Competes with Androgen for Binding to the AR in LNCaP Cells and in Recombinant AR Protein—Because our results strongly implicate the AR as the focus of the DIM mode of action in prostate cells, we assessed directly the ability of DIM to bind to this receptor. Our results of competitive binding assays with both the mutant AR of LNCaP cells and a wild-type recombinant human AR demonstrate that DIM, in the micro-molar concentration range, competes with labeled DHT for binding to the AR (Fig. 6). Cyproterone acetate and Casodex, two well known antiandrogens, were used as positive controls. DIM and Casodex exhibited similar binding affinity for the AR."
[URL unfurl="true"]https://www.jbc.org/content/278/23/21136.full[/URL]
My takeaway from the results of the study are that DIM has the potential to compete with DHT for AR activity. So while the dosage of testosterone you take is what is going to directly affect muscle size and recovery, the level of DHT does not play a role in muscular development or recovery. The proposed idea behind DIM reduces muscle hypertrophy and recovery, speculative as it may be, does bring about cause for concern. However, it doesn't appear, from this study, that DIM's anti-androgen capabilities interfere with anything beside DHT binding at the AR, which may be a good thing for many males who suffer from acne and oily skin while on TRT.
[USER=38196]@TorontoTRT[/USER] [USER=15043]@Gman86[/USER]
