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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
DHT: How High is Too High
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<blockquote data-quote="RobRoy" data-source="post: 265846" data-attributes="member: 42893"><p>Remember what you were measuring in the serum is excess and does not have any affect at the tissue level. Testosterone enters the tissue and is then converted to DHT where it then binds to the androgen receptor and then his translocated to the nucleus etc. The saturation point is the point in which the androgen receptors are fully saturated with DHT. Once you reach that saturation point raising DHT has no further affect and it's just excess. That is what you are measuring. So not only is there a saturation point of the androgen receptor but there's also a saturation point of the five alpha reductase enzyme. So you can continue to produce DHT which has no effect and measure it in the serum but there comes a point where you can't raise the DHT any further because the enzyme that creates it becomes fully saturated. That is based on the Vmax in Michaelis-Menten kinetics. So measuring DHT and making decisions off of those levels it's not based on what is actually happening in the tissues. The androgen receptors are also fully saturated a fairly low level of testosterone DHT.</p></blockquote><p></p>
[QUOTE="RobRoy, post: 265846, member: 42893"] Remember what you were measuring in the serum is excess and does not have any affect at the tissue level. Testosterone enters the tissue and is then converted to DHT where it then binds to the androgen receptor and then his translocated to the nucleus etc. The saturation point is the point in which the androgen receptors are fully saturated with DHT. Once you reach that saturation point raising DHT has no further affect and it's just excess. That is what you are measuring. So not only is there a saturation point of the androgen receptor but there's also a saturation point of the five alpha reductase enzyme. So you can continue to produce DHT which has no effect and measure it in the serum but there comes a point where you can't raise the DHT any further because the enzyme that creates it becomes fully saturated. That is based on the Vmax in Michaelis-Menten kinetics. So measuring DHT and making decisions off of those levels it's not based on what is actually happening in the tissues. The androgen receptors are also fully saturated a fairly low level of testosterone DHT. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
DHT: How High is Too High
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