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Both osteoarthritis and low levels of DHEAS are common in the elderly. Until now, however, there were no studies in human subjects concerning the relationship between them. An Italian, population-based cohort study on people over 65 years of age set out to determine the nature of the association (if any).
Adjusting for potential cofounders, subjects in the lowest tertile for DHEAS level (men and women) were found to have significantly higher odds of osteoarthritis at all three sites. Similar findings emerged for subjects in the intermediate DHEAS tertile. Low DHEAS levels are associated with osteoarthritis irrespective of gender.
"Serum dehydroepiandrosterone sulfate and osteoarthritis in older people: the Pro.V.A. study," Clinical Rheumatology, October 2016
https://www.ncbi.nlm.nih.gov/pubmed/26898983/
- Osteoarthritis was defined using a standardized disease history, medical records, symptoms, and physical examination of the hand, hip and knee.
- DHEAS levels were classified using gender-specific tertiles.
- Osteoarthritis at the three sites was far more common in women than in men.
- Osteoarthritis at the three sites was far more common in all individuals with low DHEAS levels.
Adjusting for potential cofounders, subjects in the lowest tertile for DHEAS level (men and women) were found to have significantly higher odds of osteoarthritis at all three sites. Similar findings emerged for subjects in the intermediate DHEAS tertile. Low DHEAS levels are associated with osteoarthritis irrespective of gender.
"Serum dehydroepiandrosterone sulfate and osteoarthritis in older people: the Pro.V.A. study," Clinical Rheumatology, October 2016
https://www.ncbi.nlm.nih.gov/pubmed/26898983/
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