ExcelMale
Menu
Home
What's new
Latest activity
Forums
New posts
Search forums
What's new
New posts
Latest activity
Videos
Lab Tests
Doctor Finder
Buy Books
About Us
Men’s Health Coaching
Log in
Register
What's new
Search
Search
Search titles only
By:
New posts
Search forums
Menu
Log in
Register
Navigation
Install the app
Install
More options
Contact us
Close Menu
Forums
Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
DHEA Supplementation: Have You Felt Any Effects?
JavaScript is disabled. For a better experience, please enable JavaScript in your browser before proceeding.
You are using an out of date browser. It may not display this or other websites correctly.
You should upgrade or use an
alternative browser
.
Reply to thread
Message
<blockquote data-quote="DragonBits" data-source="post: 110978" data-attributes="member: 18023"><p>At times I have taken pregnenolone and DHEA and had no effect, but I wasn't on TRT and my testosterone / estradiol were low.</p><p> </p><p>When on TRT, pregnenolone seemed to make me sleep better and I was more calm, even slept too much as I felt drowsy during the day.it also caused diarrhea and a few muscle cramps. </p><p> </p><p>I started with 50mg pregnenolone for 2 days, titrated down to 12.5 mg for 4 days, then stopped.</p><p> </p><p>DHEA 25 mgs seemed to also make me sleep better, maybe it caused some diarrhea, but I took it soon after stopping pregnenolone, so hard to tell. </p><p> </p><p>However, all this was during the initial phase of TRT before my testosterone / estradiol had risen to a higher stable level. Maybe that had an effect, or maybe my natural levels of pregnenolone and downstream hormones were still normal and not yet shutdown form TRT. I only measured my DHEA before starting TRT (not pregnenolone/ progesterone), DHEA was 958 ng/dl (309-2950) BEFORE TRT.</p><p> </p><p>I believe your levels of Vitamin D, magnesium, zinc, boron, testosterone, estradiol, etc, and the length of time you are on TRT can all interplay with pregnenolone / dhea, change the conversion pathways, also affect how the receptors in your body respond to these hormones. There are various enzymes involved in the conversions, any one of them can be affected by other nutriments in your body.</p><p>=============================================</p><p>Pregnenolone can be converted into progesterone. The critical enzyme step is two-fold using a 3&#946;-hydroxysteroid dehydrogenase and a &#916;5-4 isomerase. The latter transfers the double bond from C5 to C4 on the A ring. Progesterone is the entry into the &#916;4 pathway, resulting in production of 17&#945;-hydroxyprogesterone and androstenedione, precursor to testosterone and estrone. Aldosterone and corticosteroids are also derived from progesterone or its derivatives.</p><p>Pregnenolone can be converted to 17&#945;-hydroxypregnenolone by the enzyme 17&#945;-hydroxylase (CYP17A1). Using this pathway, termed &#916;5 pathway, the next step is conversion to dehydroepiandrosterone (DHEA) via 17,20-lyase (CYP17A1). DHEA is the precursor of androstenedione.</p><p>Pregnenolone can be converted to androstadienol by 16-ene synthase (CYP17A1).</p><p>Pregnenolone can be converted to pregnenolone sulfate by steroid sulfotransferase, and this conversion can be reversed by steroid sulfatase.</p><p></p><p><a href="https://en.wikipedia.org/wiki/Pregnenolone" target="_blank">https://en.wikipedia.org/wiki/Pregnenolone</a></p><p></p><p>===========================================</p><p></p><p>Since it's obvious pregnenolone and DHEA had physical effects for me, what I will do is try pregnenolone again in a smaller dose after being on TRT for 3-6 months. And cut DHEA to 12.5 mg for a week to see what happens. </p><p></p><p>Without pregnenolone / DHEA, it was hard to stay asleep, and I was mildly constipated. Of course, low levels of thyroid hormones can also cause the constipation.</p><p> </p><p>Male reaction to exogenous testosterone seems fairly predicable, though even with that it's going to hard to predict F testosterone and estradiol levels. </p><p> </p><p>However, from reading the various forum posts, looking at the science and seeing my own various reactions, it's way more difficult to predict how any individual might react to pregnenolone, progesterone or DHEA supplementation and what might happen </p><p> </p><p>No doubt injecting HCG could also change how one reacts to these hormonal supplements. </p><p> </p><p>It all seems so complicated to me that experimenting slowly seems the best course of action with pregnenolone / dhea / progesterone supplements. And if negative to try it again after 6 or more months to see if you still react the same way.</p></blockquote><p></p>
[QUOTE="DragonBits, post: 110978, member: 18023"] At times I have taken pregnenolone and DHEA and had no effect, but I wasn't on TRT and my testosterone / estradiol were low. When on TRT, pregnenolone seemed to make me sleep better and I was more calm, even slept too much as I felt drowsy during the day.it also caused diarrhea and a few muscle cramps. I started with 50mg pregnenolone for 2 days, titrated down to 12.5 mg for 4 days, then stopped. DHEA 25 mgs seemed to also make me sleep better, maybe it caused some diarrhea, but I took it soon after stopping pregnenolone, so hard to tell. However, all this was during the initial phase of TRT before my testosterone / estradiol had risen to a higher stable level. Maybe that had an effect, or maybe my natural levels of pregnenolone and downstream hormones were still normal and not yet shutdown form TRT. I only measured my DHEA before starting TRT (not pregnenolone/ progesterone), DHEA was 958 ng/dl (309-2950) BEFORE TRT. I believe your levels of Vitamin D, magnesium, zinc, boron, testosterone, estradiol, etc, and the length of time you are on TRT can all interplay with pregnenolone / dhea, change the conversion pathways, also affect how the receptors in your body respond to these hormones. There are various enzymes involved in the conversions, any one of them can be affected by other nutriments in your body. ============================================= Pregnenolone can be converted into progesterone. The critical enzyme step is two-fold using a 3β-hydroxysteroid dehydrogenase and a Δ5-4 isomerase. The latter transfers the double bond from C5 to C4 on the A ring. Progesterone is the entry into the Δ4 pathway, resulting in production of 17α-hydroxyprogesterone and androstenedione, precursor to testosterone and estrone. Aldosterone and corticosteroids are also derived from progesterone or its derivatives. Pregnenolone can be converted to 17α-hydroxypregnenolone by the enzyme 17α-hydroxylase (CYP17A1). Using this pathway, termed Δ5 pathway, the next step is conversion to dehydroepiandrosterone (DHEA) via 17,20-lyase (CYP17A1). DHEA is the precursor of androstenedione. Pregnenolone can be converted to androstadienol by 16-ene synthase (CYP17A1). Pregnenolone can be converted to pregnenolone sulfate by steroid sulfotransferase, and this conversion can be reversed by steroid sulfatase. [URL]https://en.wikipedia.org/wiki/Pregnenolone[/URL] =========================================== Since it's obvious pregnenolone and DHEA had physical effects for me, what I will do is try pregnenolone again in a smaller dose after being on TRT for 3-6 months. And cut DHEA to 12.5 mg for a week to see what happens. Without pregnenolone / DHEA, it was hard to stay asleep, and I was mildly constipated. Of course, low levels of thyroid hormones can also cause the constipation. Male reaction to exogenous testosterone seems fairly predicable, though even with that it's going to hard to predict F testosterone and estradiol levels. However, from reading the various forum posts, looking at the science and seeing my own various reactions, it's way more difficult to predict how any individual might react to pregnenolone, progesterone or DHEA supplementation and what might happen No doubt injecting HCG could also change how one reacts to these hormonal supplements. It all seems so complicated to me that experimenting slowly seems the best course of action with pregnenolone / dhea / progesterone supplements. And if negative to try it again after 6 or more months to see if you still react the same way. [/QUOTE]
Insert quotes…
Verification
Post reply
Share this page
Facebook
Twitter
Reddit
Pinterest
Tumblr
WhatsApp
Email
Share
Link
Sponsors
Forums
Thyroid, Pregnenolone, Progesterone, DHEA, etc
Thyroid, DHEA, Pregnenolone, Progesterone, etc
DHEA Supplementation: Have You Felt Any Effects?
This site uses cookies to help personalise content, tailor your experience and to keep you logged in if you register.
By continuing to use this site, you are consenting to our use of cookies.
Accept
Learn more…
Top