Dexamethasone Following Surgery: TRT Adversely Impacted?

CoastWatcher

Moderator
Last Friday, August 7, I underwent some rigorous outpatient surgery. A tapering dose of dexamethasone was prescribed and taken over the course of the first three days post-surgery. Having dealt with a limited course of steroids on previous occasions, I was prepared for the surge in energy/appetite/libido - and that's what happened. Forty-eight hours after the last dose I experienced the (expected) crash. No energy, slight depression, desire to sleep. But now, nearly a week later, I can't seem to shake it. My libido is slumbering, I'm sleepy, a bit of brain-fog is noticeable. All of this despite maintaining my injection and supplement schedule. is this a typical response for a patient on TRT? Just be patient and allow my system to slide back? Any thoughts are welcome.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

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Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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