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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Debate - Androgens: Estrogen ratio vs Overall Hormone Levels.
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<blockquote data-quote="Cataceous" data-source="post: 202668" data-attributes="member: 38109"><p>This subject does come up a lot. Recently <a href="https://www.excelmale.com/forum/threads/e2-what-is-high-and-low.23451/" target="_blank">here</a>, for example. Admittedly most such threads don't delve into the details, such as research on the effects of androgen levels that are high in an absolute sense, but not relative to estrogens. There seems to be a huge variation in how guys feel under such conditions, making it hard to generalize. There is some research showing that a low T/E2 ratio is problematic. It seems reasonable to assume that a high ratio could also cause issues.</p><p></p><p>Because you're on TRT you can easily experiment to see if higher relative estradiol makes you feel better; you can use estradiol cream—adopting a low-and-slow approach with the dosing, of course. I don't know if this figure is widely applicable, but I found that 100 mcg of topical estradiol daily raised serum levels around 10 pg/mL. This also seemed to correspond to about a 10% absorption rate.</p><p></p><p>DHT does oppose estradiol in scientific terms. It acts as both an aromatase inhibitor and an antagonist of the estrogen receptor. You might be interested in this post and its references:</p><p>[URL unfurl="true"]https://raypeatforum.com/community/threads/dht-is-estrogen-receptor-antagonist.10322/[/URL]</p></blockquote><p></p>
[QUOTE="Cataceous, post: 202668, member: 38109"] This subject does come up a lot. Recently [URL='https://www.excelmale.com/forum/threads/e2-what-is-high-and-low.23451/']here[/URL], for example. Admittedly most such threads don't delve into the details, such as research on the effects of androgen levels that are high in an absolute sense, but not relative to estrogens. There seems to be a huge variation in how guys feel under such conditions, making it hard to generalize. There is some research showing that a low T/E2 ratio is problematic. It seems reasonable to assume that a high ratio could also cause issues. Because you're on TRT you can easily experiment to see if higher relative estradiol makes you feel better; you can use estradiol cream—adopting a low-and-slow approach with the dosing, of course. I don't know if this figure is widely applicable, but I found that 100 mcg of topical estradiol daily raised serum levels around 10 pg/mL. This also seemed to correspond to about a 10% absorption rate. DHT does oppose estradiol in scientific terms. It acts as both an aromatase inhibitor and an antagonist of the estrogen receptor. You might be interested in this post and its references: [URL unfurl="true"]https://raypeatforum.com/community/threads/dht-is-estrogen-receptor-antagonist.10322/[/URL] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Debate - Androgens: Estrogen ratio vs Overall Hormone Levels.
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