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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Danazol to increase free testosterone and decrease estradiol?
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<blockquote data-quote="Dr Justin Saya MD" data-source="post: 91210" data-attributes="member: 12687"><p>Tough, if not impossible, to successfully use danazol long term if NOT HPTA suppressed. Too many variables as it interacts with the androgen receptors, the estrogen receptors, the progesterone receptors, and glucocorticoid receptors IN ADDITION to inhibiting many of the upstream hormone enzymes AND its interaction with SHBG. In fact, even in HPTA suppressed men it does a good job of lowering SHBG and increasing free T, yet often lags on the subjective side (likely due to the multiple/complex MOA mentioned above).</p></blockquote><p></p>
[QUOTE="Dr Justin Saya MD, post: 91210, member: 12687"] Tough, if not impossible, to successfully use danazol long term if NOT HPTA suppressed. Too many variables as it interacts with the androgen receptors, the estrogen receptors, the progesterone receptors, and glucocorticoid receptors IN ADDITION to inhibiting many of the upstream hormone enzymes AND its interaction with SHBG. In fact, even in HPTA suppressed men it does a good job of lowering SHBG and increasing free T, yet often lags on the subjective side (likely due to the multiple/complex MOA mentioned above). [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Side Effect Management
Danazol to increase free testosterone and decrease estradiol?
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