Danazol to increase free testosterone and decrease estradiol?
- Thread starter bdad
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Nelson Vergel
Founder, ExcelMale.com
Danazol is a drug used for endometriosis in women.
Some doctors prescribe it to lower sex hormone binding globulin and increase free testosterone in men (off label use not paid by insurance. Obtained from compounding pharmacies).
I have not seen data on its effects on estradiol in humans.
Since it lowers SHBG, it can also increase free estradiol (estradiol also binds to SHGB). But we do not know if this is clinically relevant.
Why don't you try it and report your free T, SHBG and estradiol to us?
https://www.excelmale.com/forum/sho...d-T-cream-or-gel-Cabergoline-and-Danazol-dose
Some doctors prescribe it to lower sex hormone binding globulin and increase free testosterone in men (off label use not paid by insurance. Obtained from compounding pharmacies).
I have not seen data on its effects on estradiol in humans.
Since it lowers SHBG, it can also increase free estradiol (estradiol also binds to SHGB). But we do not know if this is clinically relevant.
Why don't you try it and report your free T, SHBG and estradiol to us?
https://www.excelmale.com/forum/sho...d-T-cream-or-gel-Cabergoline-and-Danazol-dose
I was placed on Danazol 50 mg every day in an effort to lower SHBG and increase free T. It took my Total T from 660 to 224........ I felt terrible. Non-sensitive estrogen was normal, however, and free T was low normal. I'll go back and get the exact numbers if there is interest.
Danazol was a nightmare for me.
Danazol was a nightmare for me.
Nelson Vergel
Founder, ExcelMale.com
Danazol should NOT be taken without TRT. It is a mild androgen that shuts down T production.
Well, a well known TRT guy who's new book has been reviewed only recently with praise is the one who put me on it. It impacted me in an awful way..... Like I said, it was a nightmare.
That being said, I don't really blame him. I take a good amount of responsibility for my own health and healthcare.
That being said, I don't really blame him. I take a good amount of responsibility for my own health and healthcare.
philip brotman
New Member
i have a similar ED condition - blood work as of 2-28-16, total test 844 (250-1100 ng/dl normal
free test 29.5 (normal 30-285 pg/ml), shbg 189 (normal 22-77 nmo/dl). Was thinking of using danazol to counter high shbg, however hesitant after your experience. Do you have an update on how (or if) you have managed to decrease shbg, and have your ED symptoms decreased?
free test 29.5 (normal 30-285 pg/ml), shbg 189 (normal 22-77 nmo/dl). Was thinking of using danazol to counter high shbg, however hesitant after your experience. Do you have an update on how (or if) you have managed to decrease shbg, and have your ED symptoms decreased?
While some may suggest this falls into the realm of the "expert" TRT provider, others may opine that it's simply experimental with zero validated clinical guidelines.
On one hand pushing the envelope in the absence of guidance from large, academic centers is pioneering, on the other hand you need to realize that you may not want to be someone's guinea pig.........
philip brotman
New Member
Danazol to increase free testosterone and decrease shbg
Thank you for your reply. I am in agreement with you about lack of clinical guidelines. However, I still have to live with ED - since 2015 have you tried any other protocols to decrease your shbg, while maintaining total testosterone and enhancing free testost?
Thank you for your reply. I am in agreement with you about lack of clinical guidelines. However, I still have to live with ED - since 2015 have you tried any other protocols to decrease your shbg, while maintaining total testosterone and enhancing free testost?
I never even had high SHBG. The irresponsible maniac of a "TRT expert" often extolled as being an anointed one on forums such as these put me on it to "see if it would raise my freeT". Instead it really messed me up and impacted my life negatively, but fortunately it was recoverable.
He had me on Danazol 50 mg EOD as SOLO therapy. So be careful when someone suggests something way out of the norm.
From what I've READ, (on forums), a SHBG lowering agent can be TRIED if you are on TRT. Again, IF YOU ARE ON TRT. Danazol is a GnRH antagonist, and will shut you down hard. But, if you are already shut down and then replacing your testosterone, I can see it's plausible utility.
The egotistical push to develop a name for yourself should not mean that any TRT prescribing physician should use patients as lab rats. The problems with that are as myriad as they are serious.
***That being said, I believe we must all take responsibility for our health and healthCARE. I do not mean this post to be threatening to the individual who put my on Danazol SOLO therapy (for several months....). I am not litigious nor do I intend to smear this person in public....... It was just a really bad time for me because of the ill effects it had on me.
Last edited:
philip brotman
New Member
has anyone else had experience using Danazol for decrease of shbg, while maintaining total testosterone and enhancing free testost?
Dr Justin Saya MD
Moderator
No, not when on TRT.
CoastWatcher
Moderator
What's your SHBG?
Vince Carter
Banned
I believe you're going to need more posts to the forum before attachments are enabled for you. try something like imugr, or similar.
25.8 SHBG mnol/l
CoastWatcher
Moderator
Certainly not as low as many, but low enough that it is likely contributing to a higher free testosterone value. You did not run a total testosterone?
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