Creatine, Hematocrit, and Kidney Function..

[USMC]

Just a heads up and probably a bit of "Bro Science." I started taking 5 grams of creatine several months back. It was symptom and problem free and I got great results from it. However, in a recent blood test, my hematocrit went from 46 (where it's been for years) to 51, and my kidney function dropped 1 point. I'm guessing it is causing me to be dehydrated although I drink plenty of water. Anyway, I stopped taking the creatine for 3 weeks and got retested. My kidney function test returned to normal. I asked the DR. to include the hematocrit, but she didn't... I'm going to ask her to schedule another one to include that. Also, I see my urologist next month, so maybe she will have some input.
Note, i have been doing my prescribed TRT dose of Test C 40mg twice per week, so I doubt that increased my hematocrit.

Anyone else experience this from Creatine? I seen one other post, but I would think it would be more common with how popular Creatine is. Thanks for reading this far

Hematocrit 41.0 - 51.0 %		43.1	44.3	46.4	42.1	43.3	41.6	41.8	46.3	44.8	51.8 H
Hemoglobin 13.8 - 17.4 g/dL		14.4	14.6	15.2	14.2	14.2	13.6	14.1	15.3	14.6	17.3

 

[sammmy]

Don't know the answer to your question but in terms of testing always request CBC with differential and Comprehensive Metabolic Panel. These are inexpensive tests and carry vital general health information including the one that you need.

 

[Deleted member 43589]

Just a heads up and probably a bit of "Bro Science." I started taking 5 grams of creatine several months back. It was symptom and problem free and I got great results from it. However, in a recent blood test, my hematocrit went from 46 (where it's been for years) to 51, and my kidney function dropped 1 point. I'm guessing it is causing me to be dehydrated although I drink plenty of water. Anyway, I stopped taking the creatine for 3 weeks and got retested. My kidney function test returned to normal. I asked the DR. to include the hematocrit, but she didn't... I'm going to ask her to schedule another one to include that. Also, I see my urologist next month, so maybe she will have some input.
Note, i have been doing my prescribed TRT dose of Test C 40mg twice per week, so I doubt that increased my hematocrit.

Anyone else experience this from Creatine? I seen one other post, but I would think it would be more common with how popular Creatine is. Thanks for reading this far

Hematocrit 41.0 - 51.0 %		43.1	44.3	46.4	42.1	43.3	41.6	41.8	46.3	44.8	51.8 H
Hemoglobin 13.8 - 17.4 g/dL		14.4	14.6	15.2	14.2	14.2	13.6	14.1	15.3	14.6	17.3

Absolutely. Creatine, regardless of the source converts to creatinine as a result of energy metabolism. So creatinine is a chemical waste molecule that is generated from muscle metabolism.

Not only will creatine supplement cause a false positive, it is important to remember that even high muscle mass alone can independently correlate with high levels of serum creatinine. This is due to increased supply and turnover of creatine phosphate. High intensity training can also cause this false positive. Since creatine is in all meats, high protein diets can also cause this false positive.

I might suggest that the cystatin C blood test is better for you next time.

As far as HCT.....Robinson TM, Sewell DA, Casey A, et al. Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function.

Dietary creatine supplementation does not affect some haematological indices, or indices of muscle damage and hepatic and renal function - PubMed

These data provide evidence that there are no obvious adverse effects of acute or more chronic Cr supplementation on the haematological indices measured, nor on hepatic, muscle, and renal function. Therefore there is no apparent health risk associated with Cr supplementation to healthy people...

pubmed.ncbi.nlm.nih.gov

 

[USMC]

Absolutely. Creatine, regardless of the source converts to creatinine as a result of energy metabolism. So creatinine is a chemical waste molecule that is generated from muscle metabolism.

View attachment 34995

Not only will creatine supplement cause a false positive, it is important to remember that even high muscle mass alone can independently correlate with high levels of serum creatinine. This is due to increased supply and turnover of creatine phosphate. High intensity training can also cause this false positive. Since creatine is in all meats, high protein diets can also cause this false positive.

I might suggest that the cystatin C blood test is better for you next time.

Funny you mention that. Right below my test result it says this:
"This Cr-based equation underestimates GFR in patients with increased muscle mass. Order CYSTATIN C WITH GFR ESTIMATE, LAB4559, if additional evaluation of renal function is needed."
I messaged her about that and she responded that could very well be the case and she would consider it. ... whatever that means. Thanks for your input as always ..

 

[tareload]

Amen.

How the use of creatine supplements can elevate serum creatinine in the absence of underlying kidney pathology - PMC

Serum creatinine is a widely used marker in the assessment of renal function. Elevated creatinine levels suggest kidney dysfunction, prompting the need for further investigation. This report describes a case in which the consumption of the ...

www.ncbi.nlm.nih.gov

 

[Deleted member 43589]

Funny you mention that. Right below my test result it says this:
"This Cr-based equation underestimates GFR in patients with increased muscle mass. Order CYSTATIN C WITH GFR ESTIMATE, LAB4559, if additional evaluation of renal function is needed."
I messaged her about that and she responded that could very well be the case and she would consider it. ... whatever that means. Thanks for your input as always ..

Note, I just added the HCT part in my posting above.

 

[USMC]

Amen.

How the use of creatine supplements can elevate serum creatinine in the absence of underlying kidney pathology - PMC

Serum creatinine is a widely used marker in the assessment of renal function. Elevated creatinine levels suggest kidney dysfunction, prompting the need for further investigation. This report describes a case in which the consumption of the ...

www.ncbi.nlm.nih.gov

I think I'll message my NP and tell her I've been using Creatine. I haven't done that yet and it may change the tests I have scheduled in a couple of weeks. I'm pretty sure she plans on doing the same test we've already done.

 

[tareload]

I think I'll message my NP and tell her I've been using Creatine. I haven't done that yet and it may change the tests I have scheduled in a couple of weeks. I'm pretty sure she plans on doing the same test we've already done.

Example head to head for a swimmer physique haha.

Post in thread 'Creatinine & eGFR' Creatinine & eGFR

Docs who don't work with sicko weight lifting subculture can really give you a scare on your kidney function. Maybe that is good thing to keep us all on toes.

 

[sammmy]

Your eGFR dropped from what to what value on creatine?

 

[tareload]

Your eGFR dropped from what to what value on creatine?

Just a comparison of the two methods to estimate gfr.

One is susceptible to interference from muscle mass and creatine. Other is not.

 

[sammmy]

@USMC : Your eGFR dropped from what to what value on creatine?

 

[Vince]

expand...

When I supplement my creatine my creatinine levels go up. The normals essay combine the two and leaves you with a higher creatinine levels. Also heavy lifting will make your creatinine levels look higher. It's pretty common.

Cystatin C Test: A Game-Changer in Kidney Disease Detection - Excel Male Health Forum

Are you concerned about your kidney health? The Cystatin C test may just be a game-changer for you. This simple blood test can help in the early detection of kidney disease, allowing for timely intervention and treatment. In this blog, we will dive deep into what the Cystatin C test is, why it...

www.excelmale.com

 

[Systemlord]

Anyone else experience this from Creatine?

Creatine caused dehydration which always elevates my hematocrit. My kidney function was unchanged. I miss the extra strength during my workouts.

 

[USMC]

@USMC : Your eGFR dropped from what to what value on creatine?

Kidney function went from 62 to 57. I'm stopping creatine for my next blood test to see if it changes and I'll report back the results

 

[sammmy]

That change in eGFR is nothing, mine has gone from 60+ to 90+ depending on drugs I'm taking. Most probably is creatine in your case leading to increased creatinine production to which the eGFR is highly sensitive.

I'm not sure creatine can cause such a large jump in hematocrit though.

 

[EdinSFO]

Creatine was messing with my Hematocrit big time also so I stopped taking it.

 

[Vince]

Creatine was messing with my Hematocrit big time also so I stopped taking it.

I'm currently supplementing with 5 g of creatine daily. I started using it because of tendonitis of my Achilles tendon. So far it's working.

 

[USMC]

That change in eGFR is nothing, mine has gone from 60+ to 90+ depending on drugs I'm taking. Most probably is creatine in your case leading to increased creatinine production to which the eGFR is highly sensitive.

I'm not sure creatine can cause such a large jump in hematocrit though.

It is strange for me. My hematocrit has always been on the lower side as you can see. I haven't been adding any more Test or other goodies lately. Creatine is the only thing I added @ 5 grams per day. I stopped about a week ago and have another blood test coming up on the 11th. However, I think she (NP) is only focusing on my kidney function. I did leave a message for my DR. to consider a cystatin test, but never got a response so we'll see what tests I get. I'll report back