Crazy Sensitive to Test ??

[eli]

When I take 85mgs (14.5 slin units [36.25 E3D] ) of Testosterone a week, E2 comes back at around 18 which is low.. and I feel it. When I bumped it to 93.3mg ( 16 slin units) It goes up to 33, which is too high. my gyno starts burning and gets bigger plus ED and everything.

I was originally doing 93.3mg and dropped it to 85mgs, there were a few days when my erections were super hard, and I felt absolutely great. then after a few weeks got blood work done, e2 was low and I wasn't feeling good, so bumped it back to 93.3 and again, a few days I was feeling really good with hard erections then they went away and E2 came back at 33 again.


Does 8.3mgs really make that big of a difference ???

---------------------------------------------
Bloods on the 3rd day (I inject E3D)

85mg a week

TT: 461
FT: 21.7 (9.3 - 26)
E2: 19.7 ( 8 - 35)

8 weeks later, 93.3mg a week

TT: 508
FT: 25.3 (9.3 - 26)
E2: 33.2 ( 8 - 35)

 

[johndoesmith]

When I take 85mgs (14.5 slin units [36.25 E3D] ) of Testosterone a week, E2 comes back at around 18 which is low.. and I feel it. When I bumped it to 93.3mg ( 16 slin units) It goes up to 33, which is too high. my gyno starts burning and gets bigger plus ED and everything.

I was originally doing 93.3mg and dropped it to 85mgs, there were a few days when my erections were super hard, and I felt absolutely great. then after a few weeks got blood work done, e2 was low and I wasn't feeling good, so bumped it back to 93.3 and again, a few days I was feeling really good with hard erections then they went away and E2 came back at 33 again.


Does 8.8mgs really make that big of a difference ???

You're going to need to post more information than this in order to get any kind of advice.

1. full test results
2. When are you testing relative to injection?
3. How long are you on each dose before testing?

As it is now, I really cannot say much at all. I don't think anyone can.

 

[eli]

You're going to need to post more information than this in order to get any kind of advice.

1. full test results
2. When are you testing relative to injection?
3. How long are you on each dose before testing?

As it is now, I really cannot say much at all. I don't think anyone can.

edited/updated my first post

 

[CoastWatcher]

When I take 85mgs (14.5 slin units [36.25 E3D] ) of Testosterone a week, E2 comes back at around 18 which is low.. and I feel it. When I bumped it to 93.3mg ( 16 slin units) It goes up to 33, which is too high. my gyno starts burning and gets bigger plus ED and everything.

I was originally doing 93.3mg and dropped it to 85mgs, there were a few days when my erections were super hard, and I felt absolutely great. then after a few weeks got blood work done, e2 was low and I wasn't feeling good, so bumped it back to 93.3 and again, a few days I was feeling really good with hard erections then they went away and E2 came back at 33 again.


Does 8.3mgs really make that big of a difference ???

---------------------------------------------
Bloods on the 3rd day (I inject E3D)

85mg a week

TT: 461
FT: 21.7 (9.3 - 26)
E2: 19.7 ( 8 - 35)

8 weeks later, 93.3mg a week

TT: 508
FT: 25.3 (9.3 - 26)
E2: 33.2 ( 8 - 35)

I notice that your total testosterone comes in at a very modest level on either protocol; is 508 your highest trough reading? You referenced gynocomastia- are you dealing with actual gynocomastia, or might your nipples be responding to androgen levels being in flux?

 

[eli]

I notice that your total testosterone comes in at a very modest level on either protocol; is 508 your highest trough reading? You referenced gynocomastia- are you dealing with actual gynocomastia, or might your nipples be responding to androgen levels being in flux?

508 was 3 days after injection, just a few hrs before my next injection since i do e3d. I have gyno, a lump that gets bigger when e2 is high, but gets small and flattens when e2 is low or in sweet spot. I know when my e2 is high. My question was if it's normal to see such a big difference in e2 when test dose changes by only 8.3mg. I'm a low shbg guy 11-13, used to be 4 two years ago

 

[johndoesmith]

508 was 3 days after injection, just a few hrs before my next injection since i do e3d. I have gyno, a lump that gets bigger when e2 is high, but gets small and flattens when e2 is low or in sweet spot. I know when my e2 is high. My question was if it's normal to see such a big difference in e2 when test dose changes by only 8.3mg. I'm a low shbg guy 11-13, used to be 4 two years ago

Might just have to split your injections even more. EOD or so may be needed. Coastwatcher had to go to ED injections(every day not erectile dysfunction injections) for E2 control.

 

[eli]

Might just have to split your injections even more. EOD or so may be needed. Coastwatcher had to go to ED injections(every day not erectile dysfunction injections) for E2 control.

Yes, thought about EOD injections since I have low shbg

 

[Vince Carter]

Yes, thought about EOD injections since I have low shbg

That's the reason you're pulling these troughs that are terrible.

 

[eli]

That's the reason you're pulling these troughs that are terrible.

You think E3D to EOD will make that big off a difference?? In dropping E2 too? It's just one week that i feel great evertime I adjust dose from 93 to 85, or 85 to 93.... So I'm trying something in the middle, if that doesn't work I'll go EOD

 

[johndoesmith]

You think E3D to EOD will make that big off a difference?? In dropping E2 too? It's just one week that i feel great evertime I adjust dose from 93 to 85, or 85 to 93.... So I'm trying something in the middle, if that doesn't work I'll go EOD

Here are my labs. Everything is the same, dose, and they're at steady state, but the difference is that one I tested 48 hours after injection and the others I tested 72 hours after injection.

I follow an E3D protocol.

These are trough.





This is 48 hours after injection.

 

[Vince Carter]

SHBG is absolutely the reason for your lower troughs, indeed you may need EOD, if not daily injections to achieve stability but you're being methodical at least in working thru it. It's perplexing how you go from 93-85mg and have such a swing in your E.

 

[CoastWatcher]

You think E3D to EOD will make that big off a difference?? In dropping E2 too? It's just one week that i feel great evertime I adjust dose from 93 to 85, or 85 to 93.... So I'm trying something in the middle, if that doesn't work I'll go EOD

Many of us found success when we moved to smaller amounts of testosterone injected more frequently. Every other day or daily (my own situation) injections result in solid, stable levels of testosterone and comfortable e2 levels. A low SHBG level almost demands such a dosing schedule.

This is TRT, however, and individual results will certainly vary. But it's something you should seriously consider.

 

[eli]

so do you guys know why your SHBG is low ? I brought it to 11- 13 from 4 - 6 with the use of liver health supplements, but it's stuck there... Gonna try berberine to see if it helps.

On paper, everything looks good... Nothing wrong with me. So doctors say it's just genetics

 

[CoastWatcher]

so do you guys know why your SHBG is low ? I brought it to 11- 13 from 4 - 6 with the use of liver health supplements, but it's stuck there... Gonna try berberine to see if it helps.

On paper, everything looks good... Nothing wrong with me. So doctors say it's just genetics

Congratulations on doubling your level of SHBG, but you can spend an enormous amount of time and effort looking into SHBG levels, they whys and wherefores. However, in my own case, once metabolic syndrome, diabetes, liver disease and the other challenges that SHBG can be a marker for were eliminated, it was clear a more straightforward answer wasn't going to come. Your SHBG level is a variable that has to be considered when designing a TRT protocol, a low number calls for frequent, small injections - and they usually bring success.

In in my case, 18 months into a well-tuned protocol, my own (low) level rose. Inexplicably. As I always say, this is TRT.

 

[eli]

2 questions here

1. Going e3d to eod tonight, how long til i notice the difference? Also will shbg increas since im lowering my dose and doing eod as opposrd to a highrr dose e3d

 

[Vince Carter]

2 questions here

1. Going e3d to eod tonight, how long til i notice the difference? Also will shbg increas since im lowering my dose and doing eod as opposrd to a highrr dose e3d

\

MY SHBG never went up as I moved up the frequency, last time I tested it on daily inj it was @ 12. No one can say beyond the typical test in 4-6 weeks how you'll feel.

 

[eli]

I have read some members saying their shbg increased went they did eod or ED. Hope that'll be the case for me too

 

[ERO]

The thing with SHBG is that if you are low (like I am) raising it a few points is typically not enough to help. My last SHBG test was 7, so I would need to raise mine like 400% to get it to 28, as an example. Still, I hope you are the exception and that you get a solid raise in your level.

 

[Vince Carter]

The thing with low SHBG that you want to definitely check out but be cautious with giving it undue concern is that some like to toss around scary conditions that they think are associated with low SHBG, like: Diabetes, fatty liver, and metabolic syndrome. All things are are prudent overall to assess and eliminate but don't jump to conclusions like those. Most all of us with low SHBG find it to be "normal" for us with no known cause or other underlying issue.

 

[eli]

The thing with low SHBG that you want to definitely check out but be cautious with giving it undue concern is that some like to toss around scary conditions that they think are associated with low SHBG, like: Diabetes, fatty liver, and metabolic syndrome. All things are are prudent overall to assess and eliminate but don't jump to conclusions like those. Most all of us with low SHBG find it to be "normal" for us with no known cause or other underlying issue.

No medical conditions, I also have low HDL (34) doc says it's all genetics at this point