Couple subtle changes in 8 weeks, since last blood work

[tom1959]

>T has remained consistent. Free T has plummeted in pa 6 week from 30ngdl to 7ng/dl.
>Estradoil has dropped from 94 (sensitive) to 10, using Arimidex .25 EOD
>Hematocrit is still in range but increased 4 percentage points, since last test 6 weeks ago. Over the past year, never seen this type of change.

Protocol: 10-200MG pellets, very (4) months. DEX .2 EOD.

I did stop using DEX mid way through my last round of pellets, Estradiol dropped to 3.

I still feel good but got these result by surprise. Thoughts? Advice?

[TH="class: hl7FirstCol"]Description [/TH]	Out-of-Range	In-Range	Units	Expected	Abnormal Flag	Status
005009 CBC With Differential/Platelet
[TD="class: hl7FirstCol"]005025 - WBC[/TD]		6.0	x10E3/uL	3.4-10.8		F
[TD="class: hl7FirstCol"]005033 - RBC[/TD]		5.26	x10E6/uL	4.14-5.80		F
[TD="class: hl7FirstCol"]005041 - Hemoglobin[/TD]		16.4	g/dL	12.6-17.7		F
[TD="class: hl7FirstCol"]005058 - Hematocrit[/TD]		47.2	%	37.5-51.0		F
[TD="class: hl7FirstCol"]015065 - MCV[/TD]		90	fL	79-97		F
[TD="class: hl7FirstCol"]015073 - MCH[/TD]		31.2	pg	26.6-33.0		F
[TD="class: hl7FirstCol"]015081 - MCHC[/TD]		34.7	g/dL	31.5-35.7		F
[TD="class: hl7FirstCol"]105007 - RDW[/TD]		13.6	%	12.3-15.4		F
[TD="class: hl7FirstCol"]015172 - Platelets[/TD]		278	x10E3/uL	150-379		F
[TD="class: hl7FirstCol"]015107 - Neutrophils[/TD]		60	%			F
[TD="class: hl7FirstCol"]015123 - Lymphs[/TD]		26	%			F
[TD="class: hl7FirstCol"]015131 - Monocytes[/TD]		9	%			F
[TD="class: hl7FirstCol"]015149 - Eos[/TD]		4	%			F
[TD="class: hl7FirstCol"]015156 - Basos[/TD]		1	%			F
[TD="class: hl7FirstCol abnVal"]115398 - Immature Cells[/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"]X[/TD]
[TD="class: hl7FirstCol"]015909 - Neutrophils (Absolute)[/TD]		3.6	x10E3/uL	1.4-7.0		F
[TD="class: hl7FirstCol"]015917 - Lymphs (Absolute)[/TD]		1.6	x10E3/uL	0.7-3.1		F
[TD="class: hl7FirstCol"]015925 - Monocytes(Absolute)[/TD]		0.6	x10E3/uL	0.1-0.9		F
[TD="class: hl7FirstCol"]015933 - Eos (Absolute)[/TD]		0.2	x10E3/uL	0.0-0.4		F
[TD="class: hl7FirstCol"]015941 - Baso (Absolute)[/TD]		0.1	x10E3/uL	0.0-0.2		F
[TD="class: hl7FirstCol"]015108 - Immature Granulocytes[/TD]		0	%			F
[TD="class: hl7FirstCol"]015911 - Immature Grans (Abs)[/TD]		0.0	x10E3/uL	0.0-0.1		F
[TD="class: hl7FirstCol abnVal"]015945 - NRBC[/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"]X[/TD]
[TD="class: hl7FirstCol abnVal"]015180 - Hematology Comments:[/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"]X[/TD]
322000 Comp. Metabolic Panel (14)
[TD="class: hl7FirstCol"]001032 - Glucose, Serum[/TD]		85	mg/dL	65-99		F
[TD="class: hl7FirstCol"]001040 - BUN[/TD]		17	mg/dL	6-24		F
[TD="class: hl7FirstCol abnVal"]001370 - Creatinine, Serum[/TD] [TD="class: abnVal"]1.37[/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"]mg/dL[/TD] [TD="class: abnVal"]0.76-1.27[/TD] [TD="class: abnVal"]H[/TD] [TD="class: abnVal"]F[/TD]
[TD="class: hl7FirstCol abnVal"]100791 - eGFR If NonAfricn Am[/TD] [TD="class: abnVal"]58[/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"]mL/min/1.73[/TD] [TD="class: abnVal"] >59[/TD] [TD="class: abnVal"]L[/TD] [TD="class: abnVal"]F[/TD]
[TD="class: hl7FirstCol"]100797 - eGFR If Africn Am[/TD]		67	mL/min/1.73	>59		F
[TD="class: hl7FirstCol"]011577 - BUN/Creatinine Ratio[/TD]		12		9-20		F
[TD="class: hl7FirstCol"]001198 - Sodium, Serum[/TD]		143	mmol/L	134-144		F
[TD="class: hl7FirstCol"]001180 - Potassium, Serum[/TD]		3.9	mmol/L	3.5-5.2		F
[TD="class: hl7FirstCol"]001206 - Chloride, Serum[/TD]		98	mmol/L	97-108		F
[TD="class: hl7FirstCol"]001578 - Carbon Dioxide, Total[/TD]		28	mmol/L	18-29		F
[TD="class: hl7FirstCol"]001016 - Calcium, Serum[/TD]		9.2	mg/dL	8.7-10.2		F
[TD="class: hl7FirstCol"]001073 - Protein, Total, Serum[/TD]		6.1	g/dL	6.0-8.5		F
[TD="class: hl7FirstCol"]001081 - Albumin, Serum[/TD]		4.4	g/dL	3.5-5.5		F
[TD="class: hl7FirstCol"]012039 - Globulin, Total[/TD]		1.7	g/dL	1.5-4.5		F
[TD="class: hl7FirstCol abnVal"]012047 - A/G Ratio[/TD] [TD="class: abnVal"]2.6[/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"]1.1-2.5[/TD] [TD="class: abnVal"]H[/TD] [TD="class: abnVal"]F[/TD]
[TD="class: hl7FirstCol"]001099 - Bilirubin, Total[/TD]		0.3	mg/dL	0.0-1.2		F
[TD="class: hl7FirstCol"]001107 - Alkaline Phosphatase, S[/TD]		64	IU/L	39-117		F
[TD="class: hl7FirstCol"]001123 - AST (SGOT)[/TD]		27	IU/L	0-40		F
[TD="class: hl7FirstCol"]001545 - ALT (SGPT)[/TD]		20	IU/L	0-44		F
140103 Testosterone,Free and Total
[TD="class: hl7FirstCol abnVal"]004227 - Testosterone, Serum[/TD] [TD="class: abnVal"]1468[/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"]ng/dL[/TD] [TD="class: abnVal"]348-1197[/TD] [TD="class: abnVal"]H[/TD] [TD="class: abnVal"]F[/TD]
[TD="class: hl7FirstCol abnVal"]001179 - Comment:[/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"]F[/TD]
[TD="class: hl7NoteRow, colspan: 7"]Adult male reference interval is based on a population of lean males[/TD]
[TD="class: hl7NoteRow, colspan: 7"]up to 40 years old.[/TD]
[TD="class: hl7FirstCol"]144981 - Free Testosterone(Direct)[/TD]		7.3	pg/mL	7.2-24.0		F
004283 Luteinizing Hormone(LH), S
[TD="class: hl7FirstCol abnVal"]004290 - LH[/TD] [TD="class: abnVal"]0.1[/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"]mIU/mL[/TD] [TD="class: abnVal"]1.7-8.6[/TD] [TD="class: abnVal"]L[/TD] [TD="class: abnVal"]F[/TD]
004309 FSH, Serum
[TD="class: hl7FirstCol abnVal"]004316 - FSH[/TD] [TD="class: abnVal"]0.4[/TD] [TD="class: abnVal"][/TD] [TD="class: abnVal"]mIU/mL[/TD] [TD="class: abnVal"]1.5-12.4[/TD] [TD="class: abnVal"]L[/TD] [TD="class: abnVal"]F[/TD]
004515 Estradiol
[TD="class: hl7FirstCol"]004519 - Estradiol[/TD]		30.2	pg/mL	7.6-42.6		F
[TD="class: hl7NoteRow, colspan: 7"]Roche ECLIA methodology[/TD]
010322 Prostate-Specific Ag, Serum
[TD="class: hl7FirstCol"]010334 - Prostate Specific Ag, Serum[/TD]		1.7	ng/mL	0.0-4.0		F
[TD="class: hl7NoteRow, colspan: 7"]Roche ECLIA methodology.[/TD]
[TD="class: hl7NoteRow, colspan: 7"] .[/TD]
[TD="class: hl7NoteRow, colspan: 7"]According to the American Urological Association, Serum PSA should[/TD]
[TD="class: hl7NoteRow, colspan: 7"]decrease and remain at undetectable levels after radical[/TD]
[TD="class: hl7NoteRow, colspan: 7"]prostatectomy. The AUA defines biochemical recurrence as an initial[/TD]
[TD="class: hl7NoteRow, colspan: 7"]PSA value 0.2 ng/mL or greater followed by a subsequent confirmatory[/TD]
[TD="class: hl7NoteRow, colspan: 7"]PSA value 0.2 ng/mL or greater.[/TD]
[TD="class: hl7NoteRow, colspan: 7"]Values obtained with different assay methods or kits cannot be used[/TD]
[TD="class: hl7NoteRow, colspan: 7"]interchangeably. Results cannot be interpreted as absolute evidence[/TD]
[TD="class: hl7NoteRow, colspan: 7"]of the presence or absence of malignant disease.[/TD]
140244 Estradiol, Sensitive
[TD="class: hl7FirstCol"]140246 - Estradiol, Sensitive[/TD]		10	pg/mL	3-70		F
[TD="class: hl7NoteRow, colspan: 7"] Male Female[/TD]
[TD="class: hl7NoteRow, colspan: 7"] 0- 6 yrs. 0 - 15 0 - 15[/TD]
[TD="class: hl7NoteRow, colspan: 7"] 7-10 yrs. 0 - 15 0 - 70[/TD]
[TD="class: hl7NoteRow, colspan: 7"] 11-12 yrs. 0 - 40 10 - 300[/TD]
[TD="class: hl7NoteRow, colspan: 7"] 13-15 yrs. 0 - 45 10 - 300[/TD]
[TD="class: hl7NoteRow, colspan: 7"] >15 yrs. 3 - 70 See Below[/TD]
[TD="class: hl7NoteRow, colspan: 7"] Ovulating Female[/TD]
[TD="class: hl7NoteRow, colspan: 7"] Follicular Phase 9 - 175[/TD]
[TD="class: hl7NoteRow, colspan: 7"] Luteal Phase 44 - 196[/TD]
[TD="class: hl7NoteRow, colspan: 7"] Periovulatory 107 - 281[/TD]
[TD="class: hl7NoteRow, colspan: 7"] Oral Contraceptives 0 - 91[/TD]
[TD="class: hl7NoteRow, colspan: 7"] Postmenopausal[/TD]
[TD="class: hl7NoteRow, colspan: 7"] Treated 42 - 289[/TD]
[TD="class: hl7NoteRow, colspan: 7"] Untreated 0 - 19[/TD]
[TD="class: hl7NoteRow, colspan: 7"] .[/TD]
[TD="class: hl7NoteRow, colspan: 7"] Estradiol results obtained with different[/TD]
[TD="class: hl7NoteRow, colspan: 7"] assay methods cannot be used interchangeably.[/TD]
[TD="class: hl7NoteRow, colspan: 7"] It is recommended that only one assay method[/TD]
[TD="class: hl7NoteRow, colspan: 7"] be used consistently to monitor serial[/TD]
[TD="class: hl7NoteRow, colspan: 7"] patient results.[/TD]

 

[Gene Devine]

IMO you need to cut back on your use of the AI. Your E2 using the "Sensitive" assay of 10 is too low. Anything below 20 is unhealthy for a male. Best for men is between 25 - 35 pg/ml.

I don't see SHBG labs.

You say: "Free T has plummeted in pa 6 week from 30 ng/dl to 7ng/dl"... but I don't see a value for Free Testosterone on your labs?

Your Doctor should have immediate concerns regarding your low Free Testosterone serum levels relative to your supraphysiological Total Testosterone levels if this is the case.

One significant cause of this is elevated SHBG which securely binds to Testosterone rendering the hormone useless and why Free Testosterone levels are low.

You need to get SHBG labs run to see if this is a cause.

All that Total Testosterone is not doing you a lot of good with such low Free Testosterone.