Could Popular Weight Loss Drugs Help Prevent Cancer?

madman

Super Moderator


In this episode, Dr. Diane Reidy-Lagunes sits down with MSK’s Dr. Neil Iyengar, a nationally recognized expert on the relationship between obesity, metabolic health, and cancer. Together, they discuss the intriguing connection between a new class of weight loss drugs, called GLP-1 agonists, and cancer risk reduction. They explore how medications like Ozempic, Wegovy, Mounjaro and others, which were originally designed for diabetes, are not only effective for weight loss but may also lower the risk of developing obesity-related cancers. They explain how those drugs work within the body to deliver potential benefits, the limitations of current studies, and what weight loss drugs mean for both cancer prevention and treatment.




Episode Chapters:


0:00 - Intro
1:35 - How do these drugs cause weight loss?
3:08 - What cancers could these drugs help prevent?
4:29 - How exactly do they prevent cancer?
6:10 - Should people with cancer take these drugs?
7:42 - What happens when you stop taking them?
10:56 - Potential side effects
12:25 - Limitations of recent study and breast cancer prevention
14:36 - 3 lifestyle tips to prevent and treat cancer
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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