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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Controlling Estrogen with Arimidex?
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<blockquote data-quote="madman" data-source="post: 261435" data-attributes="member: 13851"><p>Welcome Nikolay!</p><p></p><p><em><strong>*I switched to 125mg for a few weeks but I was feeling down, slept like 12 hours a day so I switched to 150mg.</strong></em></p><p></p><p>Two big red flags here.</p><p></p><p>Going from one extreme 500 mg T/week--->125 mg T/week off the hop and increasing your dose 2 weeks in.</p><p></p><p>You need to understand how this works when using exogenous esterified T.</p><p></p><p>You went from injecting an absurd dose of T 500 mg/week (12 week cycle) right down to a therapeutic dose (100-150 mg) used for TRT.</p><p></p><p>Anyone would feel like shit going from one extreme to the other off the hop.</p><p></p><p>Your T levels would be taking a nose dive from where they sat on cycle.</p><p></p><p>Shock to your system especially when it come to the CNS.</p><p></p><p>If anything you should have lowered your dose every week until you reached a sensible starting TRT dose which for most is 100 mg T/week and better yet split twice weekly (50 mg T every 3.5 days).</p><p></p><p>This would have made the transition much easier.</p><p></p><p>Most men on TRT can easily achieve a healthy/high trough FT level on 100-150 mg T/week especially when split into more frequent injections.</p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/sleep-question.26473/#post-238838[/URL]</p><p></p><p></p><p></p><p>Key point here:</p><p></p><p><strong><em>*Following the initiation of testosterone therapy, serum concentrations of testosterone are known to correct earlier than the symptomatic, structural, and metabolic signs associated with TD.76,77</em></strong></p><p></p><p></p><p>[URL unfurl="true"]https://www.excelmale.com/forum/threads/canadian-urology-guideline-on-testosterone-replacement.22972/[/URL]</p><p></p><p><strong>26.What is a reasonable timeline to begin to observe improvements in the signs and symptoms of testosterone deficiency?</strong></p><p><strong></strong></p><p><strong><em>*Following the initiation of testosterone therapy, serum concentrations of testosterone are known to correct earlier than the symptomatic, structural, and metabolic signs associated with TD.76,77 <u>As such, patients should be counseled that symptom response will not be immediate</u>. <u>Expectations for treatment response should be established with each patient</u>. <u>Patients can anticipate improvements in many of the common symptoms of TD (libido, energy levels, sexual function) after 3 months of treatment or longer</u>. <u>Metabolic and structural (body composition, muscle mass, bone density) changes may take upwards of 6 months</u>. 77 In addition, patients should be counseled that diet and exercise in combination with testosterone therapy are recommended for body composition changes.</em></strong></p><p><strong><em></em></strong></p><p><strong><em>*<u>Appreciating this pattern of response to testosterone therapy is fundamental when determining the impact of treatment and the appropriate timing of follow-up evaluations while on therapy</u>. <u>For example, if patients undergo a symptom review and measurement of testosterone levels too early (< 3 months), it may lead both physicians and patients to conclude that the treatment has not been impactful (i.e. normal levels of testosterone without symptomatic, structural, metabolic benefit)</u>. <u>However, if the same assessment was scheduled 3-6 months after the initiation of therapy, the clinical response tends to be more reflective of normalized levels of serum testosterone</u>.</em></strong></p><p></p><p></p><p></p><p></p><p>My reply from previous threads regarding elevated estradiol and use of an AI.</p><p></p><p>Can be a slippery slope when relying on an aromatase inhibitor to try and manage elevated estradiol as in many cases one can easily crash e2 if they are not careful.</p><p></p><p>Too many end up overmedicating.</p><p></p><p>The sensible ones are using micro-doses.</p><p></p><p>Even then there are many that are running way too high a trough FT level and could easily avoid use of an AI by lowering their dose.</p><p></p><p>Too many still caught up on that more T is better mentality.</p><p></p><p>Running too high an FT can be just as bad in the long run as having a low FT in many ways.</p><p></p><p>As I have stated numerous times on the forum we need to tread lightly when trying to manipulate testosterone metabolites estradiol and DHT as they are needed in healthy amounts and are critical to our overall health.</p><p></p><p>Estradiol and DHT are needed in healthy amounts to experience the full spectrum of testosterones beneficial effects on mood, energy, libido, erectile function, cardiovascular health, brain, bones, tendons, immune system, body composition, and recovery.</p><p></p><p><em><strong>*Natural testosterone is viewed as the best androgen for substitution in hypogonadal men. The reason behind the selection is that testosterone can be <u>converted to DHT and E2</u>, thus developing the full spectrum of testosterone activities in long-term substitution</strong></em></p></blockquote><p></p>
[QUOTE="madman, post: 261435, member: 13851"] Welcome Nikolay! [I][B]*I switched to 125mg for a few weeks but I was feeling down, slept like 12 hours a day so I switched to 150mg.[/B][/I] Two big red flags here. Going from one extreme 500 mg T/week--->125 mg T/week off the hop and increasing your dose 2 weeks in. You need to understand how this works when using exogenous esterified T. You went from injecting an absurd dose of T 500 mg/week (12 week cycle) right down to a therapeutic dose (100-150 mg) used for TRT. Anyone would feel like shit going from one extreme to the other off the hop. Your T levels would be taking a nose dive from where they sat on cycle. Shock to your system especially when it come to the CNS. If anything you should have lowered your dose every week until you reached a sensible starting TRT dose which for most is 100 mg T/week and better yet split twice weekly (50 mg T every 3.5 days). This would have made the transition much easier. Most men on TRT can easily achieve a healthy/high trough FT level on 100-150 mg T/week especially when split into more frequent injections. [URL unfurl="true"]https://www.excelmale.com/forum/threads/sleep-question.26473/#post-238838[/URL] Key point here: [B][I]*Following the initiation of testosterone therapy, serum concentrations of testosterone are known to correct earlier than the symptomatic, structural, and metabolic signs associated with TD.76,77[/I][/B] [URL unfurl="true"]https://www.excelmale.com/forum/threads/canadian-urology-guideline-on-testosterone-replacement.22972/[/URL] [B]26.What is a reasonable timeline to begin to observe improvements in the signs and symptoms of testosterone deficiency? [I]*Following the initiation of testosterone therapy, serum concentrations of testosterone are known to correct earlier than the symptomatic, structural, and metabolic signs associated with TD.76,77 [U]As such, patients should be counseled that symptom response will not be immediate[/U]. [U]Expectations for treatment response should be established with each patient[/U]. [U]Patients can anticipate improvements in many of the common symptoms of TD (libido, energy levels, sexual function) after 3 months of treatment or longer[/U]. [U]Metabolic and structural (body composition, muscle mass, bone density) changes may take upwards of 6 months[/U]. 77 In addition, patients should be counseled that diet and exercise in combination with testosterone therapy are recommended for body composition changes. *[U]Appreciating this pattern of response to testosterone therapy is fundamental when determining the impact of treatment and the appropriate timing of follow-up evaluations while on therapy[/U]. [U]For example, if patients undergo a symptom review and measurement of testosterone levels too early (< 3 months), it may lead both physicians and patients to conclude that the treatment has not been impactful (i.e. normal levels of testosterone without symptomatic, structural, metabolic benefit)[/U]. [U]However, if the same assessment was scheduled 3-6 months after the initiation of therapy, the clinical response tends to be more reflective of normalized levels of serum testosterone[/U].[/I][/B] My reply from previous threads regarding elevated estradiol and use of an AI. Can be a slippery slope when relying on an aromatase inhibitor to try and manage elevated estradiol as in many cases one can easily crash e2 if they are not careful. Too many end up overmedicating. The sensible ones are using micro-doses. Even then there are many that are running way too high a trough FT level and could easily avoid use of an AI by lowering their dose. Too many still caught up on that more T is better mentality. Running too high an FT can be just as bad in the long run as having a low FT in many ways. As I have stated numerous times on the forum we need to tread lightly when trying to manipulate testosterone metabolites estradiol and DHT as they are needed in healthy amounts and are critical to our overall health. Estradiol and DHT are needed in healthy amounts to experience the full spectrum of testosterones beneficial effects on mood, energy, libido, erectile function, cardiovascular health, brain, bones, tendons, immune system, body composition, and recovery. [I][B]*Natural testosterone is viewed as the best androgen for substitution in hypogonadal men. The reason behind the selection is that testosterone can be [U]converted to DHT and E2[/U], thus developing the full spectrum of testosterone activities in long-term substitution[/B][/I] [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
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Controlling Estrogen with Arimidex?
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