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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Complete opposite results from similar dosages.
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<blockquote data-quote="Cataceous" data-source="post: 217429" data-attributes="member: 38109"><p>Forcing down SHBG in isolation should not have much effect on free testosterone. Instead it drives down total testosterone. This does imply conventional wisdom has been incorrect. I've been guilty of promulgating such myself. It's good to keep an open mind and question beliefs that may not have firm foundations.</p><p></p><p>You can increase free testosterone by either raising the dose, or in theory by decreasing your metabolic clearance rate.</p><p></p><p>As noted, lowering SHBG lowers total T, not free T. Regarding the phenotype, the first factor is that the dose is high for a guy on TRT. For a natural guy it would be a naturally high set point for free testosterone. The second factor is that SHBG is naturally low and/or has been driven down by the relatively high free testosterone. This latter turns around the causality in the association by saying that it's elevated free testosterone that's pushing down SHBG.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 217429, member: 38109"] Forcing down SHBG in isolation should not have much effect on free testosterone. Instead it drives down total testosterone. This does imply conventional wisdom has been incorrect. I've been guilty of promulgating such myself. It's good to keep an open mind and question beliefs that may not have firm foundations. You can increase free testosterone by either raising the dose, or in theory by decreasing your metabolic clearance rate. As noted, lowering SHBG lowers total T, not free T. Regarding the phenotype, the first factor is that the dose is high for a guy on TRT. For a natural guy it would be a naturally high set point for free testosterone. The second factor is that SHBG is naturally low and/or has been driven down by the relatively high free testosterone. This latter turns around the causality in the association by saying that it's elevated free testosterone that's pushing down SHBG. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Complete opposite results from similar dosages.
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