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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Complete opposite results from similar dosages.
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<blockquote data-quote="Cataceous" data-source="post: 217259" data-attributes="member: 38109"><p>The misconception occurs in part because higher SHBG with fixed total testosterone results in lower free testosterone. But that is not a physiological situation. With TRT, or even with a normal HPTA, there is a relatively constant input of testosterone, which drives a relatively constant free testosterone, so that excretion matches intake. This is independent of SHBG. Thus total testosterone, and not free testosterone, is driven by SHBG. The assumptions made to reach this conclusion are straightforward. Which ones do you think are wrong?</p><p></p><p>As far as I can see the articles are offering no evidence. The associations may exist, but do not show causality. Can you locate any studies that directly demonstration a causal relationship? These have to account for confounding factors, such as higher free testosterone acting on the liver to reduce SHBG.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 217259, member: 38109"] The misconception occurs in part because higher SHBG with fixed total testosterone results in lower free testosterone. But that is not a physiological situation. With TRT, or even with a normal HPTA, there is a relatively constant input of testosterone, which drives a relatively constant free testosterone, so that excretion matches intake. This is independent of SHBG. Thus total testosterone, and not free testosterone, is driven by SHBG. The assumptions made to reach this conclusion are straightforward. Which ones do you think are wrong? As far as I can see the articles are offering no evidence. The associations may exist, but do not show causality. Can you locate any studies that directly demonstration a causal relationship? These have to account for confounding factors, such as higher free testosterone acting on the liver to reduce SHBG. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Blood Test Discussion
Complete opposite results from similar dosages.
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