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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Complete apathy/depression from too high E2?
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<blockquote data-quote="Cataceous" data-source="post: 185158" data-attributes="member: 38109"><p>Normal men produce 3-9 mg testosterone per day. You are taking 17. Accounting for a lack of diurnal variation puts your dose at effectively 14 mg, still quite high.</p><p></p><p>If you are not using an accurate free testosterone test—equilibrium dialysis or ultrafiltration—then you cannot rely on the results. The Tru-T calculator is a reasonable alternative, and it has a healthy normal range 16-31 ng/dL. Though not the last word, this calculator suggests that even with very high SHBG your total testosterone of 900-1,000 ng/dL should put free T well into the healthy range.</p><p></p><p>While initial stabilization of serum testosterone can take as much as four to six weeks, you may experience a reduction in SHBG over an even longer period. One effect of this is to lower total testosterone while free testosterone is static, assuming the same TRT dose pattern.</p><p></p><p>With your parameters I would get some basic blood work: testosterone, estradiol, SHBG and albumin. If free testosterone is high then I would go for a dose reduction and then a longer settling period. If free testosterone is a little low then I would just wait for further stabilization. Only if it's quite low would I consider an increase.</p></blockquote><p></p>
[QUOTE="Cataceous, post: 185158, member: 38109"] Normal men produce 3-9 mg testosterone per day. You are taking 17. Accounting for a lack of diurnal variation puts your dose at effectively 14 mg, still quite high. If you are not using an accurate free testosterone test—equilibrium dialysis or ultrafiltration—then you cannot rely on the results. The Tru-T calculator is a reasonable alternative, and it has a healthy normal range 16-31 ng/dL. Though not the last word, this calculator suggests that even with very high SHBG your total testosterone of 900-1,000 ng/dL should put free T well into the healthy range. While initial stabilization of serum testosterone can take as much as four to six weeks, you may experience a reduction in SHBG over an even longer period. One effect of this is to lower total testosterone while free testosterone is static, assuming the same TRT dose pattern. With your parameters I would get some basic blood work: testosterone, estradiol, SHBG and albumin. If free testosterone is high then I would go for a dose reduction and then a longer settling period. If free testosterone is a little low then I would just wait for further stabilization. Only if it's quite low would I consider an increase. [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Complete apathy/depression from too high E2?
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