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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Complete apathy/depression from too high E2?
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<blockquote data-quote="E-Gen" data-source="post: 185132" data-attributes="member: 41159"><p>I started TRT 5 weeks ago on 24mg/day subcutaneous injections of Test C (168mg/week). My doc put me on a relatively high dose because my SHBG is very high (maybe 2-3 standard deviations out of range), so much so that despite having naturally high TT levels, my FT was in the dumpster all the way at the bottom of the range and I had all the symptoms of low T despite a pretty much perfect lifestyle.</p><p></p><p>I am lean (12-13% BF) and physically in shape (work out regularly). Low BP and heart rate, very high HDL and low LDL, all my other health markers are great. I'm 42yo.</p><p></p><p>I started out feeling good, motivated and focused for the first time in many years, but after 3 weeks or so I started feeling terrible again and even worse than I felt before TRT. I'm having suicidal thoughts, sleep 12 hours a day, am completely apathetic towards life and have crazy brain fog. I've lost interest in everything including sex, which is something I'm typically always excited about.</p><p></p><p>I asked my doc if it was possible I overshot my "good zone" and now have Test and E2 way too high, and he said my symptoms sound more like low Test and low E2, probably because my current dose doesn't even get me to where my TT was before TRT (it was very high), and because my SHBG is so high my FT is currently even lower than it was before TRT..</p><p></p><p>He recommended I bump up my dose to 30mg/day (210mg/week) and do blood tests in 3 weeks or so. Is it possible my symptoms are from high Test and high E2 instead of low Test and low E2? It seems apathy, fatigue and depression are usually signs of low E2 but I'm not sure. I'm thinking maybe I should just run tests myself monday and see where things are before tinkering anymore with my levels.</p><p></p><p>Any thoughts?</p></blockquote><p></p>
[QUOTE="E-Gen, post: 185132, member: 41159"] I started TRT 5 weeks ago on 24mg/day subcutaneous injections of Test C (168mg/week). My doc put me on a relatively high dose because my SHBG is very high (maybe 2-3 standard deviations out of range), so much so that despite having naturally high TT levels, my FT was in the dumpster all the way at the bottom of the range and I had all the symptoms of low T despite a pretty much perfect lifestyle. I am lean (12-13% BF) and physically in shape (work out regularly). Low BP and heart rate, very high HDL and low LDL, all my other health markers are great. I'm 42yo. I started out feeling good, motivated and focused for the first time in many years, but after 3 weeks or so I started feeling terrible again and even worse than I felt before TRT. I'm having suicidal thoughts, sleep 12 hours a day, am completely apathetic towards life and have crazy brain fog. I've lost interest in everything including sex, which is something I'm typically always excited about. I asked my doc if it was possible I overshot my "good zone" and now have Test and E2 way too high, and he said my symptoms sound more like low Test and low E2, probably because my current dose doesn't even get me to where my TT was before TRT (it was very high), and because my SHBG is so high my FT is currently even lower than it was before TRT.. He recommended I bump up my dose to 30mg/day (210mg/week) and do blood tests in 3 weeks or so. Is it possible my symptoms are from high Test and high E2 instead of low Test and low E2? It seems apathy, fatigue and depression are usually signs of low E2 but I'm not sure. I'm thinking maybe I should just run tests myself monday and see where things are before tinkering anymore with my levels. Any thoughts? [/QUOTE]
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Testosterone Replacement, Low T, HCG, & Beyond
Testosterone Basics & Questions
Complete apathy/depression from too high E2?
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